Skip to main content
Log in

The RING domain of human promyelocytic leukemia protein (PML)

  • NMR structure note
  • Published:
Journal of Biomolecular NMR Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  • Bernardi R, Pandolfi PP (2007) Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol 8:1006–1016

    Article  Google Scholar 

  • Borden KL, Boddy MN, Lally J, O’Reilly NJ, Martin S, Howe K, Solomon E, Freemont PS (1995) The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML. EMBO J 14:1532–1541

    Google Scholar 

  • Carracedo A, Ito K, Pandolfi PP (2011) The nuclear bodies inside out: PML conquers the cytoplasm. Curr Opin Cell Biol 23:360–366

    Article  Google Scholar 

  • Chu Y, Yang X (2011) SUMO E3 ligase activity of TRIM proteins. Oncogene 30:1108–1116

    Article  Google Scholar 

  • Cornilescu G, Delaglio F, Bax A (1999) Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR 13:289–302

    Article  Google Scholar 

  • Deshaies RJ, Joazeiro CA (2009) RING domain E3 ubiquitin ligases. Annu Rev Biochem 78:399–434

    Article  Google Scholar 

  • Duprez E, Saurin AJ, Desterro JM, Lallemand-Breitenbach V, Howe K, Boddy MN, Solomon E, de The H, Hay RT, Freemont PS (1999) SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation. J Cell Sci 112(Pt 3):381–393

    Google Scholar 

  • Freemont PS, Hanson IM, Trowsdale J (1991) A novel cysteine-rich sequence motif. Cell 64:483–484

    Article  Google Scholar 

  • Guntert P (2009) Automated structure determination from NMR spectra. Eur Biophys J Biophys Lett 38:129–143

    Article  Google Scholar 

  • Huang SY, Naik MT, Chang CF, Fang PJ, Wang YH, Shih HM, Huang TH (2014) NMR structure note: the B-box 1 dimer of human promyelocytic leukemia protein. J Biomol NMR 60:275–281

    Article  Google Scholar 

  • Jensen K, Shiels C, Freemont PS (2001) PML protein isoforms and the RBCC/TRIM motif. Oncog Res 20:7223–7233

    Article  Google Scholar 

  • Koradi R, Billeter M, Wüthrich K (1996) MOLMOL: a program for display and analysis of macromolecular structures. J Mol Gr 14:51–55

    Article  Google Scholar 

  • Kornhaber G, Snyder D, Moseley HB, Montelione G (2006) Identification of zinc-ligated cysteine residues based on 13Cα and 13Cβ chemical shift data. J Biomol NMR 34:259–269

    Article  Google Scholar 

  • Kung CC, Naik MT, Wang SH, Shih HM, Chang CC, Lin LY, Chen CL, Ma C, Chang CF, Huang TH (2014) Structural analysis of poly-SUMO chain recognition by RNF4-SIMs domain. Biochem J 462:53–65

    Article  Google Scholar 

  • Lallemand-Breitenbach V, Zhu J, Puvion F, Koken M, Honore N, Doubeikovsky E, Duprez E, Pandol PP, Puvion E, Freemont PS, de The H (2001) Role of promyelocytic leukemia (pml) sumolation in nuclear body formation, 11 s proteasome recruitment, and As2o3-induced PML or PML/retinoic acid receptor α degradation. J Exp Med 193:1361–1371

    Article  Google Scholar 

  • Laskowski RA, Rullmann JAC, MacArthur MW, Kaptein R, Thornton JM (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR 8:477–486

    Article  Google Scholar 

  • Lefevre JF, Dayie KT, Peng JW, Wagner G (1996) Internal mobility in the partially folded DNA binding and dimerization domains of GAL4: NMR analysis of the N-H spectral density functions. Biochemistry 35:2674–2686

    Article  Google Scholar 

  • Markley JL, Bax A, Arata Y, Hilbers CW, Kaptein R, Sykes BD, Wright PE, Wuthrich K (1998) Recommendations for the presentation of NMR structures of proteins and nucleic acids. IUPAC-IUBMB-IUPAB inter-union task group on the standardization of data bases of protein and nucleic acid structures determined by NMR spectroscopy. J Biomol NMR 12:1–23

    Article  Google Scholar 

  • Meroni G (2012) Genomics and evolution of the TRIM gene family. Adv Exp Med Biol 770:1–9

    Article  Google Scholar 

  • Metzger MB, Pruneda JN, Klevit RE, Weissman AM (2014) RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination. Biochim Et Biophys Acta Mol Cell Res 1843:47–60

    Article  Google Scholar 

  • Pickart CM (2001) Mechanisms underlying ubiquitination. Annu Rev Biochem 70:503–533

    Article  Google Scholar 

  • Schmidt E, Guntert P (2012) A New algorithm for reliable and general NMR resonance assignment. J Am Chem Soc 134:12817–12829

    Article  Google Scholar 

  • Sudmeier JL, Bradshaw EM, Haddad KEC, Day RM, Thalhauser CJ, Bullock PA, Bachovchin WW (2003) Identification of histidine tautomers in proteins by 2D 1H/13Cδ2 one-bond correlated NMR. J Am Chem Soc 125:8430–8431

    Article  Google Scholar 

  • Tatham MH, Geoffroy MC, Shen L, Plechanovova A, Hattersley N, Jaffray EG, Palvimo JJ, Hay RT (2008) RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol 10:538–546

    Article  Google Scholar 

  • Wishart DS, Sykes BD (1994) Chemical shifts as a tool for structure determination. Methods Enzymol 239:363–392

    Article  Google Scholar 

Download references

Acknowledgments

The NMR experiments were conducted on NMR spectrometers at the High-Field Nuclear Magnetic Resonance Center (HFNMRC), supported by the National Research Program for Biopharmaceuticals, the National Science Council of the Republic of China. We acknowledge the use of Biophysics Core Facility at Academia Sinica, Taiwan. This work was supported by grants from the Ministry of Science and Technology, Republic of China, to T.H.H. (NSC101-2311-B-001-025; NSC102-2113-M-001-010).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Tai-huang Huang.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 162 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, SY., Chang, CF., Fang, PJ. et al. The RING domain of human promyelocytic leukemia protein (PML). J Biomol NMR 61, 173–180 (2015). https://doi.org/10.1007/s10858-015-9901-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10858-015-9901-3

Keywords

Navigation