Skip to main content
SpringerLink
Log in

Solution structure of a putative FKBP-type peptidyl-propyl cis–trans isomerase from Giardia lamblia

  • NMR Structure Note
  • Published:
Journal of Biomolecular NMR Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  • Alag R, Qureshi IA, Bharatham N, Shin J, Lescar J, Yoon HS (2010) NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35. Protein Sci 19(8):1577–1586

    Article  Google Scholar 

  • Bell A, Wernli B, Franklin RM (1994) Roles of peptidyl-prolyl cis–trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin. Biochem Pharmacol 48(3):495–503

    Article  Google Scholar 

  • Bhattacharjya S, Tejero R, Montelione GT (2007) Evaluating protein structures determined by structural genomics consortia. Proteins 66(4):778–795

    Article  Google Scholar 

  • Buchko GW, Daughdrill GW, de Lorimier R, Rao S, Isern NG, Lingbeck J, Taylor J-S, Wold MS, Gochin M, Spicer LD, Lowry DF, Kennedy MA (1999) Interactions of human nucleotide excision repair protein XPA with DNA and RPA70ΔC327: chemical shift mapping and 15N NMR relaxation studies. Biochemistry 38(46):15116–15128

    Article  Google Scholar 

  • Burkhard P, Taylor P, Walkinshaw MD (2000) X-ray structure of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J Mol Biol 295(4):953–962

    Article  Google Scholar 

  • Chakraborty G, Shin J, Nguyen QT, Harikishore A, Baek K, Yoon HS (2012) Solution structure of FK5606-binding protein 12 from Aedes aegypti. Proteins 80:2476–2481

    Article  Google Scholar 

  • Choi R, Kelly A, Hewitt SN, Napuli AJ, Van Voorhis WC (2011) Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallograhic structure success. Acta Cryst F67(9):998–1005

    Google Scholar 

  • Göthel SF, Marahiel MA (1999) Peptidyl-propyl cis–trans isomerases, a superfamily of ubiquitous folding catalysts. Cell Mol Life Sci 55(3):423–436

    Article  Google Scholar 

  • Gouet P, Courcelle E, Stuart DI, Metoz F (1999) ESPript: analysis of multiple sequence alignments in postscript. Bioinformatics 15(4):305–308

    Article  Google Scholar 

  • Holm L, Rosenström P (2010) Dali server: conservation mapping in 3D. Nucl Acids Res 38(S2):W545–W549

    Article  Google Scholar 

  • Kotaka M, Ye H, Alag R, Hu G, Bozdech Z, Preiser PR, Yoon HS, Lescar J (2008) Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in comples with FK506. Biochemistry 47(22):5951–5961

    Article  Google Scholar 

  • Krappus KD, Lundgren RG, Juranek DD, Roberts JM, Spencer HC (1994) Intestinal parasitism in the United States: update on a continuing problem. Am J Trop Med Hyg 50(6):705–713

    Google Scholar 

  • Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Lopez R, Thompson JD, Gibson TJ, Higgins DG (2007) ClustalW and ClustalX version 2.0. Bioinformatics 23(21):2947–2948

    Article  Google Scholar 

  • Liang J, Hung DT, Schreiber SL, Clardy J (1996) Structure of the human 25 kDa binding domain protein complexed with rapamycin. J Am Chem Soc 118(5):1231–1232

    Article  Google Scholar 

  • Moro A, Ruiz-Cabello F, Fernández-Cano A, Stock RP, González A (1995) Secretion by Trypanosoma cruzi of a peptidyl-propyl cis–trans isomerase involved in cell infection. EMBO J 14(3):2483–2490

    Google Scholar 

  • Morrison HG, McArthur AG, Gillin FD, Aley SB, Adam RD, Olsen GJ, Best AA, Cande WZ, Chen F, Cipriano MJ, Davids BJ, Dawson SC, Elmendorf HG, Hehl AB, Holder ME, Huse SM, Kim UU, Lasek-Nesselquist E, Manning G, Nigam A, Nixon JE, Palm D, Passamaneck NE, Prabhu A, Reich CI, Reiner DS, Samuelson J, Svard SG, Sogin ML (2007) Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science 317(5846):1921–1926

    Article  ADS  Google Scholar 

  • Myler PJ, Stacy R, Stewart LJ, Staker BL, Van Voorhis WC, Varani G, Buchko GW (2009) The Seattle Structural Genomics Center for Infectious Disease (SSGCID). Infect Dis Drug Targets 9(5):493–506

    Article  Google Scholar 

  • Savioli L, Smith H, Thompson A (2006) Giardia and cryptosporidium join the “neglected diseases initiative”. Trends Parasitol 22(5):203–208

    Article  Google Scholar 

  • Szyperski T, Yeh DC, Sukumaran DK, Moseley HNB, Montelione GT (2002) Reduced-dimensionality NMR spectroscopy for high-throughput protein resonance assignment. Proc Natl Acad Sci USA 99(12):8009–8014

    Article  ADS  Google Scholar 

  • Zuiderweg ERP (2002) Mapping protein–protein interactions in solution using NMR spectroscopy. Biochemistry 41(1):1–7

    Article  Google Scholar 

Download references

Acknowledgments

Funding for this research was provided by the National Institute of Allergy and Infectious Diseases, National Institute of Health, Department of Health and Human Services, under Federal Contract numbers HHSN272201200025C and HHSN272200700057C. The SSGCID internal ID for Gl-FKBP is GilaA.00840.a. Much of this research was performed at the W.R. Wiley Environmental Molecular Sciences Laboratory (EMSL), a national scientific user facility located at Pacific Northwest National Laboratory (PNNL) and sponsored by U.S. Department of Energy’s Office of Biological and Environmental Research (BER) program. Battelle operates PNNL for the U.S. Department of Energy.

Author information

Authors and Affiliations

  1. Seattle Structural Genomics Center for Infectious Disease, Seattle, WA, USA

    Garry W. Buchko, Stephen N. Hewitt, Wesley C. Van Voorhis & Peter J. Myler

  2. Biological Sciences Division, Biochemistry and Structural Biology, Pacific Northwest National Laboratory, Richland, WA, 99352, USA

    Garry W. Buchko

  3. Department of Medicine, University of Washington, Seattle, WA, 98185-7185, USA

    Stephen N. Hewitt & Wesley C. Van Voorhis

  4. Seattle Biomedical Research Institute, Seattle, WA, 98109-5219, USA

    Peter J. Myler

  5. Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, 98195, USA

    Peter J. Myler

  6. Department of Global Health, University of Washington, Seattle, WA, 98195, USA

    Peter J. Myler

Authors
  1. Garry W. Buchko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stephen N. Hewitt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wesley C. Van Voorhis
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peter J. Myler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Garry W. Buchko.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Buchko, G.W., Hewitt, S.N., Van Voorhis, W.C. et al. Solution structure of a putative FKBP-type peptidyl-propyl cis–trans isomerase from Giardia lamblia . J Biomol NMR 57, 369–374 (2013). https://doi.org/10.1007/s10858-013-9797-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10858-013-9797-8

Keywords

Search

Navigation