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Solution Structure of Human Dihydrofolate Reductase in its Complex with Trimethoprim and NADPH

  • NMR structure note
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Abbreviations

DHFR:

dihydrofolate reductase

hDHFR:

human dihydrofolate reductase

MTX:

methotrexate

PDB:

Protein Data Bank

TMP:

trimethoprim

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Author information

Authors and Affiliations

  1. Center for Drug Chemistry, Moscow, 119815 , Russia

    Nadezhda V. Kovalevskaya & Vladimir I. Polshakov

  2. Center for Magnetic Tomography and Spectroscopy, M.V. Lomonosov Moscow State University, Moscow, 119992, Russia

    Yegor D. Smurnyy & Vladimir I. Polshakov

  3. Division of Molecular Structure, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, U.K.

    Berry Birdsall, Alan F. Bradbury & James Feeney

  4. MRC Biomedical NMR Centre, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, U.K.

    Tom Frenkiel

Authors
  1. Nadezhda V. Kovalevskaya
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  2. Yegor D. Smurnyy
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  3. Vladimir I. Polshakov
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  4. Berry Birdsall
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  5. Alan F. Bradbury
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  6. Tom Frenkiel
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  7. James Feeney
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Corresponding author

Correspondence to James Feeney.

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Kovalevskaya, N.V., Smurnyy, Y.D., Polshakov, V.I. et al. Solution Structure of Human Dihydrofolate Reductase in its Complex with Trimethoprim and NADPH. J Biomol NMR 33, 69–72 (2005). https://doi.org/10.1007/s10858-005-1475-z

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  • DOI: https://doi.org/10.1007/s10858-005-1475-z

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