The role Beta-cyclodextrin (βCD) on improving biocompatibility on healthy cellular and animal models was studied upon a formulation obtained from the development of a simple coating procedure. The obtained nanosystems were thoroughly characterized by FTIR, TGA, atomic absorption spectroscopy, dynamic light scattering and zeta potential, TEM/HR-TEM and magnetic properties. βCD might interact with the magnetic core through hosting OA. It is feasible that the nanocomposite is formed by nanoparticles of MG@OA dispersed in a βCD matrix. The evaluation of βCD role on biocompatibility was performed on two healthy models. To this end, in vivo studies were carried out on Caenorhabditis elegans. Locomotion and progeny were evaluated after exposure animals to MG, MG@OA, and MG@OA-βCD (10 to 500 µg/mL). The influence of βCD on cytotoxicity was explored in vitro on healthy rat aortic endothelial cells, avoiding alteration in the results derived from the use of transformed cell lines. Biological studies demonstrated that βCD attaching improves MG biocompatibility.
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Authors thank Dr Diego Rayes for his kind support during the assays on C. elegans. This work was supported by “Consejo Nacional de Investigaciones Científicas y Técnicas” (CONICET) and “Universidad Nacional del Sur” (UNS).
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Agotegaray, M., Blanco, M.G., Campelo, A. et al. β-cyclodextrin coating: improving biocompatibility of magnetic nanocomposites for biomedical applications. J Mater Sci: Mater Med 31, 22 (2020). https://doi.org/10.1007/s10856-020-6361-4