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3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications

Journal of Materials Science: Materials in Medicine volume 31, Article number: 113 (2020) Cite this article

Abstract

Osteochondral defects affect both of cartilage and subchondral areas, thus it poses a significant challenge to simultaneously regenerate two parts in orthopedics. Tissue engineering strategy is currently regarded as the most promising way to repair osteochondral defects. This study focuses on developing a multilayered scaffold with enhanced interface bonding through 3D printing. One-shot printing process enables control over material composition, pore structure, and size in each region of the scaffold, while realizes seamlessly integrated construct as well. The scaffold was designed to be triphasic: a porous bone layer composed of alginate sodium (SA) and mesoporous bioactive glasses (MBG), an intermediate dense layer also composed of SA and MBG and a cartilaginous layer composed of SA. The mechanical strength including the interface adhesion strength between layers were characterized. The results indicated that SA crosslinking after 3D printing anchored different materials together and integrated all regions. Additional scaffold soaking in simulated body fluid (SBF) and cell culture medium induced apatite deposition and had weakened the compressive and tensile strengths, while no layer dislocation or delamination occurred.

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Acknowledgements

The authors gratefully acknowledge support a grant from the Shanghai Natural Science Foundation (No.19ZR1435100) and National Natural Science Foundation of China (No.51673212).

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Authors and Affiliations

  1. School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai, PR China

    Min Zhu, Xin He, Chen Xin & Yufang Zhu

  2. Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, PR China

    Zhongtang Liu

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  1. Min Zhu
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Correspondence to Min Zhu or Zhongtang Liu.

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Zhu, M., He, X., Xin, C. et al. 3D printing of an integrated triphasic MBG-alginate scaffold with enhanced interface bonding for hard tissue applications. J Mater Sci: Mater Med 31, 113 (2020). https://doi.org/10.1007/s10856-020-06459-6

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  • DOI: https://doi.org/10.1007/s10856-020-06459-6

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