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A novel lidocaine hydrochloride mucoadhesive films for periodontal diseases

  • Biomaterials Synthesis and Characterization
  • Original Research
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Periodontal diseases are inflammatory disorders caused primarily by dental plaque microorganisms that even may need surgery to remove damaged tissue. Adhesive biocompatible films may be an adequate form in order to improve drug retention or prevent microbial infections by covering the surgical site. In recent years, much attention has been focused on biocompatible inexpensive polymers, for biomedical and pharmaceutical potential applications. The objective of this research is the development of a film for mucosal application containing lidocaine hydrochloride (5%, w/w) as anesthetic drug. Lidocaine films were prepared with three biopolymers: hydroxypropylmethylcellulose (HPMC), chitosan (CH), or xanthan gum (XG). Their thickness and uniformity content were characterized. Rheological behavior of the hydrated films was studied using flow curves, creep and recovery tests and dynamic oscillatory measurements with a rheometer. The mucoadhesive assays were carried out with cheeks of Wistar rat using a universal tensile tester to know their adhesiveness. Finally, lidocaine delivery through the films was investigated in Franz cells. All films (n = 3 for each polymer) showed flexibility, a drug content of 0.015 ± 0.001 g/cm2 and a thickness of 0.25 ± 0.01 mm. The results of the maximum detachment force in tensile tests and work adhesion indicated that XG is the polymer that showed greater power of mucoadhesion (p < 0.05). These properties show a good correlation with the rheological characteristics. In all cases, the lidocaine amount released at 30 min is around 4 mg/cm2. This amount could be considered sufficient to guarantee the anesthetic effect.

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Authors and Affiliations

  1. Department of Pharmacy, Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain

    María Pleguezuelos-Villa, Amparo Nácher, María Barrachina, Nuria Peñalver & Octavio Díez-Sales

  2. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat deValència, Av. Vicent Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain

    Amparo Nácher & Octavio Díez-Sales

  3. Department of Earth Physics and Thermodynamics, Faculty of Physics, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain

    María Jesús Hernández

  4. Department of Physical Chemistry, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100, Burjassot, Valencia, Spain

    M. A. Ofelia Vila Busó

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  1. María Pleguezuelos-Villa
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  2. Amparo Nácher
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  3. María Jesús Hernández
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  4. M. A. Ofelia Vila Busó
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Correspondence to María Pleguezuelos-Villa.

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Pleguezuelos-Villa, M., Nácher, A., Hernández, M.J. et al. A novel lidocaine hydrochloride mucoadhesive films for periodontal diseases. J Mater Sci: Mater Med 30, 14 (2019). https://doi.org/10.1007/s10856-018-6213-7

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  • DOI: https://doi.org/10.1007/s10856-018-6213-7

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