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A novel lidocaine hydrochloride mucoadhesive films for periodontal diseases

  • María Pleguezuelos-VillaEmail author
  • Amparo Nácher
  • María Jesús Hernández
  • M. A. Ofelia Vila Busó
  • María Barrachina
  • Nuria Peñalver
  • Octavio Díez-Sales
Biomaterials Synthesis and Characterization Original Research
  • 230 Downloads
Part of the following topical collections:
  1. Biomaterials Synthesis and Characterization

Abstract

Periodontal diseases are inflammatory disorders caused primarily by dental plaque microorganisms that even may need surgery to remove damaged tissue. Adhesive biocompatible films may be an adequate form in order to improve drug retention or prevent microbial infections by covering the surgical site. In recent years, much attention has been focused on biocompatible inexpensive polymers, for biomedical and pharmaceutical potential applications. The objective of this research is the development of a film for mucosal application containing lidocaine hydrochloride (5%, w/w) as anesthetic drug. Lidocaine films were prepared with three biopolymers: hydroxypropylmethylcellulose (HPMC), chitosan (CH), or xanthan gum (XG). Their thickness and uniformity content were characterized. Rheological behavior of the hydrated films was studied using flow curves, creep and recovery tests and dynamic oscillatory measurements with a rheometer. The mucoadhesive assays were carried out with cheeks of Wistar rat using a universal tensile tester to know their adhesiveness. Finally, lidocaine delivery through the films was investigated in Franz cells. All films (n = 3 for each polymer) showed flexibility, a drug content of 0.015 ± 0.001 g/cm2 and a thickness of 0.25 ± 0.01 mm. The results of the maximum detachment force in tensile tests and work adhesion indicated that XG is the polymer that showed greater power of mucoadhesion (p < 0.05). These properties show a good correlation with the rheological characteristics. In all cases, the lidocaine amount released at 30 min is around 4 mg/cm2. This amount could be considered sufficient to guarantee the anesthetic effect.

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • María Pleguezuelos-Villa
    • 1
    Email author
  • Amparo Nácher
    • 1
    • 2
  • María Jesús Hernández
    • 3
  • M. A. Ofelia Vila Busó
    • 4
  • María Barrachina
    • 1
  • Nuria Peñalver
    • 1
  • Octavio Díez-Sales
    • 1
    • 2
  1. 1.Department of Pharmacy, Pharmaceutical Technology and Parasitology, Faculty of PharmacyUniversity of ValenciaValenciaSpain
  2. 2.Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de ValènciaUniversitat deValènciaValenciaSpain
  3. 3.Department of Earth Physics and Thermodynamics, Faculty of PhysicsUniversity of ValenciaValenciaSpain
  4. 4.Department of Physical Chemistry, Faculty of PharmacyUniversity of ValenciaValenciaSpain

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