A novel lidocaine hydrochloride mucoadhesive films for periodontal diseases
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Periodontal diseases are inflammatory disorders caused primarily by dental plaque microorganisms that even may need surgery to remove damaged tissue. Adhesive biocompatible films may be an adequate form in order to improve drug retention or prevent microbial infections by covering the surgical site. In recent years, much attention has been focused on biocompatible inexpensive polymers, for biomedical and pharmaceutical potential applications. The objective of this research is the development of a film for mucosal application containing lidocaine hydrochloride (5%, w/w) as anesthetic drug. Lidocaine films were prepared with three biopolymers: hydroxypropylmethylcellulose (HPMC), chitosan (CH), or xanthan gum (XG). Their thickness and uniformity content were characterized. Rheological behavior of the hydrated films was studied using flow curves, creep and recovery tests and dynamic oscillatory measurements with a rheometer. The mucoadhesive assays were carried out with cheeks of Wistar rat using a universal tensile tester to know their adhesiveness. Finally, lidocaine delivery through the films was investigated in Franz cells. All films (n = 3 for each polymer) showed flexibility, a drug content of 0.015 ± 0.001 g/cm2 and a thickness of 0.25 ± 0.01 mm. The results of the maximum detachment force in tensile tests and work adhesion indicated that XG is the polymer that showed greater power of mucoadhesion (p < 0.05). These properties show a good correlation with the rheological characteristics. In all cases, the lidocaine amount released at 30 min is around 4 mg/cm2. This amount could be considered sufficient to guarantee the anesthetic effect.
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Conflict of interest
The authors declare that they have no conflict of interest.
- 14.Mura C, Nácher A, Merino V, Merino-Sanjuan M, Carda C, Ruiz A, Manconi M, Loy G, Fadda AM, Díez-Sales O. N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: In vivo study with TNBS-induced colitis model in rats. Int J Pharm. 2011;416:145–54.Google Scholar
- 16.Mezger TG. The rheology handbook. 4th ed. Hanover: Vincentz Network; 2014.Google Scholar
- 18.Barnes HA. A handbook of elementary rheology. Aberystwyth: University of Wales, Institute of Non-Newtonian Fluid Mechanics; 2000.Google Scholar
- 20.Dolz M, Corrias F, Díez-Sales O, Casanovas A, Hernández MJ. Influence of test times on creep and recovery behavior of xanthan gum hydrogels. Appl Rheol. 2009;19:34201–8.Google Scholar
- 33.Carafa M, Marianecci C, Di Marzio L, Rinaldi F, Meo C, Matricardi P. A new vesicle-loaded hydrogel system suitable for topical applications: preparation and characterization. J Pharm Sci. 2011;14:336–46.Google Scholar
- 37.Vermani K, Garg S, Zaneveld Lourens JD. Assemblies for in vitro measurement of bioadhesive strength and retention characteristics in simulated vaginal environment. Drug Dev Ind Pharm.2004;28(9):995–1004.Google Scholar