Skip to main content

Advertisement

SpringerLink
Log in

Improvement of anti-washout property of calcium phosphate cement by addition of konjac glucomannan and guar gum

  • Biomaterials Synthesis and Characterization
  • Original Research
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstracts

The inferior anti-washout property of injectable calcium phosphate cement (CPC) limits its wider application in clinic. In this study, the improvement of anti-washout performance of CPC by addition of konjac glucomannan or guar gum, which was dissolved in the CPC liquid, was first studied. The influence of KGM/GG blend with different mass ratios on the anti-washout property, compressive strength and in vitro cytocompatibility of CPC was estimated. The results revealed that small amount of KGM or GG could obviously enhance the anti-washout property of CPC. Moreover, the washout resistance efficiency of KGM/GG blend was better than KGM or GG alone. The addition of KGM/GG blend slightly shortened the final setting time of CPC. Although the introduction of KGM/GG blend reduced the compressive strength of CPC, the compressive strength still reached or surpassed that of human cancellous bone. The best KGM/GG mass ratio was 5:5, which was most efficient at not only reducing CPC disintegration, but also increasing compressive strength. The addition of KGM/GG blend obviously promoted the cells proliferation on the CPC. In short, the CPC modified by KGM/GG blend exhibited excellent anti-washout property, appropriate setting time, adequate compressive strength, and good cytocompatibility, and has the potential to be used in bone defect repair.

The addition of KGM/GG blend significantly improved the anti-washout property of CPC. The best KGM/GG mass ratio was 5:5, which was most efficient in reducing the CPC disintegration.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  1. Brown WE, Chow LC. A new calcium phosphate, water-setting cement. Cements research progress. Wester Westerville, OH: American Ceramic Society; 1986. pp. 352–79.

  2. Fernández E, Gil FJ, Ginebra MP, Driessens FCM, Planell JA, Best SM. Calcium phosphate bone cements for clinical applications, Part I. Solution chemistry. J Mater Sci Mater Med. 1999;10:169–76.

    Article  Google Scholar 

  3. Fernández E, Gil FJ, Ginebra MP, Driessens FCM, Planell JA, Best SM. Calcium phosphate bone cements for clinical applications. Part II: Precipitate formation during setting reactions. J Mater Sci Mater Med. 1999;10:177–83.

    Article  Google Scholar 

  4. Wang XH, Ma JB, Wang YN, He BL. Bone repair in radii and tibias of rabbits with phosphorylated chitosan reinforced calcium phosphate cements. Biomaterials. 2002;23:4167–76.

    Article  CAS  Google Scholar 

  5. Guo DG, Xu KW, Zhao XY, Han Y. Development of a strontium-containing hydroxyapatite bone cement. Biomaterials. 2005;26:4073–83.

    Article  CAS  Google Scholar 

  6. Wang XP, Ye JD, Wang YJ, Wu XP, Bai B. Control of crystallinity of hydrated products in a calcium phosphate bone cement. J Biomed Mater Res Part A. 2007;81A:781–90.

    Article  CAS  Google Scholar 

  7. Qi XP, Ye JD, Wang YJ. Improved injectability and in vitro degradation of a calcium phosphate cement containing poly(lactide-co-glycolide) microspheres. Acta Biomater. 2008;4:1837–45.

    Article  CAS  Google Scholar 

  8. Li XM, He FP, Ye JD. Preparation, characterization and in vitro cell performance of anti-washout calcium phosphate cement modified by sodium polyacrylate. RSC Adv. 2017;7:32842–49.

    Article  CAS  Google Scholar 

  9. Wang XP, Chen L, Xiang H, Ye JD. Influence of anti-washout agents on the rheological properties and injectability of a calcium phosphate cement. J Biomed Mater Res Part B Appl Biomater. 2007;81B:410–8.

    Article  CAS  Google Scholar 

  10. Liu JQ, Li JY, Ye JD, He FP. Setting behavior, mechanical property and biocompatibility of anti-washout wollastonite/calcium phosphate composite cement. Ceram Int. 2016;42:13670–81.

    Article  CAS  Google Scholar 

  11. Liu JQ, Li JY, Ye JD. Properties and cytocompatibility of anti-washout calcium phosphate cement by introducing locust bean gum. J Mater Sci Technol. 2016;32:1021–6.

    Article  Google Scholar 

  12. Chen FP, Song ZY, Liu CS. Fast setting and anti-washout injectable calcium–magnesium phosphate cement for minimally invasive treatment of bone defects. J Mater Chem B. 2015;3:9173–81.

    Article  CAS  Google Scholar 

  13. Cherng A, Takagi S, Chow LC. Effects of hydroxypropyl methylcellulose and other gelling agents on the handling properties of calcium phosphate cement. J Biomed Mater Res. 1995;35:273–7.

    Article  Google Scholar 

  14. Ishikawa K, Miyamoto Y, Kon M, Nagayama M, Asaoka K. Non-decay type fast-setting calcium phosphate cement: composite with sodium alginate. Biomaterials. 1995;16:527–32.

    Article  CAS  Google Scholar 

  15. El-Fiqi A, Kim JH, Perez RA, Kim HW. Novel bioactive nanocomposite cement formulations with potential properties: incorporation of the nanoparticle form of mesoporous bioactive glass into calcium phosphate cements. J Mater Chem B. 2015;7:1321–34.

    Article  Google Scholar 

  16. Huang L, Takahashi R, Kobayashi S, Kawase T, Nishinari K. Gelation behavior of native and acetylated konjac glucomannan. Biomacromolecules. 2002;3:1296–303.

    Article  CAS  Google Scholar 

  17. Yoshimura M, Takaya T, Nishinari K. Rheological studies on mixtures of corn starch and konjac-glucomannan. Carbohyd Polym. 1997;35:71–9.

    Article  Google Scholar 

  18. Nishinari K, Williams PA, Phillips GO. Review of the physico-chemical characteristics and properties of konjac mannan. Food Hydrocoll. 1992;6:199–222.

    Article  CAS  Google Scholar 

  19. Maekaji K. Determination of acidic component of konjac mannan. Agric Biol Chem. 1978;42:177–8.

    CAS  Google Scholar 

  20. Zhang FS, Shen YD, Ren T, Wang L, Su Y. Synthesis of 2-alkenyl-3-butoxypropyl guar gum with enhanced rheological properties. Int J Biol Macromol. 2017;97:317–22.

    Article  CAS  Google Scholar 

  21. Vijayendran BR, Bone T. Absolute molecular weight and molecular weight distribution of guar by size exclusion chromatography and low-angle laser light scattering. Carbohyd Polym. 1984;4:299–313.

    Article  CAS  Google Scholar 

  22. Wang XP, Ye JD, Wang YJ. Hydration mechanism of a novel PCCP + DCPA cement system. J Mater Sci Mater Med. 2008;19:813–16.

    Article  CAS  Google Scholar 

  23. Kokubo T, Takadama H. How useful is SBF in predicting in vivo bone bioactivity. Biomaterials. 2006;27:2907–15.

    Article  CAS  Google Scholar 

  24. Barralet JE, Gaunt T, Wright AJ, Gibson IR, Knowles JC. Effect of porosity reduction by compaction on compressive strength and microstructure of calcium phosphate cement. J Biomed Mater Res. 2001;63:1–9.

    Article  Google Scholar 

  25. Bose S, Darsell J, Kintner M, Hosick H, Bandyopadhyay A. Pore size and pore volume effects on alumina and TCP ceramic scaffolds. Mat Sci Eng C-Mater. 2003;23:479–86.

    Article  Google Scholar 

  26. Chen ZT, Ni SY, Han SG, Crawford R, Lu S, Wei F, Chang J, Wu CT, Xiao Y. Nanoporous microstructures mediate osteogenesis by modulating the osteo-immune response of macrophages. Nanoscale. 2017;9:706–18.

    Article  CAS  Google Scholar 

  27. Langer R, Tirrell DA. Designing materials for biology and medicine. Nature. 2004;428:487–92.

    Article  CAS  Google Scholar 

  28. Lotz JC, Gehart TN, Hayes WC. Mechanical properties of trabecular bone from the proximal femur: a quantitative CT study. J Comput Assist Tomogr. 1990;14:107–14.

    Article  CAS  Google Scholar 

  29. Nie HR, Shen XX, Zhou ZH, Jiang QS, Chen YW, Xie A, Wang Y, Han CC. Electrospinning and characterization of konjac glucomannan/chitosan nanofibrous scaffolds favoring the growth of bone mesenchymal stem cells. Carbohyd Polym. 2011;85:681–6.

    Article  CAS  Google Scholar 

  30. Kundu S, Das A, Basu A, Ghosh D, Datta P, Mukherjee A. Carboxymethyl guar gum synthesis in homogeneous phase and macroporous 3D scaffolds design for tissue engineering. Carbohyd Polym. 2018;191:71–8.

    Article  CAS  Google Scholar 

  31. Tiwari A, Grailer JJ, Pilla S, Steeber DA, Gong SQ. Biodegradable hydrogels based on novel photopolymerizable guar gum–methacrylate macromonomers for in situ fabrication of tissue engineering scaffolds. Acta Biomater. 2009;5:441–3452.

    Article  Google Scholar 

Download references

Acknowledgements

This research was supported by the National Natural Science Foundation of China under Grant No. 51672087, the Science and Technology Program of Guangzhou City of China under Grant No. 201508020017, and the Fundamental Research Funds for the Central Universities. The authors declare that they have no conflict of interest.

Author information

Author notes

  1. These authors contributed equally: Guowen Qian, Xingmei Li.

Authors and Affiliations

  1. School of Materials Science and Engineering, South China University of Technology, 510641, Guangzhou, China

    Guowen Qian, Xingmei Li & Jiandong Ye

  2. National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, 510006, Guangzhou, China

    Guowen Qian, Xingmei Li & Jiandong Ye

  3. School of Electromechanical Engineering, Guangdong University of Technology, 510006, Guangzhou, China

    Fupo He

  4. Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, 510006, Guangzhou, China

    Jiandong Ye

Authors
  1. Guowen Qian
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xingmei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fupo He
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jiandong Ye
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiandong Ye.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qian, G., Li, X., He, F. et al. Improvement of anti-washout property of calcium phosphate cement by addition of konjac glucomannan and guar gum. J Mater Sci: Mater Med 29, 183 (2018). https://doi.org/10.1007/s10856-018-6193-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s10856-018-6193-7

Search

Navigation