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Preparation and cytocompatibility of a novel bismuth aluminate/calcium phosphate cement with high radiopacity

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

In a minimally invasive surgery, using a bone cement being radiologically detectable is vital to the success of the procedure and avoiding cement leakage in the early stage. The radiopacity of calcium phosphate cement (CPC) is inadequate, thus limiting its clinic application in this area. In this work, bismuth aluminate (BiA) was employed as a radiopaque agent for CPC. The influences of BiA on physicochemical, radiopaque and in vitro biocompatible properties of CPC were investigated. With the increasing content of BiA, the setting time and the compressive strength of CPC were augmented, while the injectability of the cement pastes was reduced. The radiopacity of CPC was significantly improved by adding more than 6 wt.% BiA. CPC specimens with less than 12 wt.% BiA showed good cellular affinity. Moreover, the CPC containing 6 and 9 wt.% BiA promoted the cell growth and ALP activity of mouse bone marrow mesenchymal stem cells when compared with the control. On the basis of its improved radiopacity and cytocompatibility, the radiopaque CPC with 6 ~ 9 wt.% BiA is expected to be a potential substitute for bone defect restoration via minimally invasive surgery.

CPC with bismuth aluminate reveals better radiopacity and cell affinity along with proper physicochemical properties.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (NSFC) under Grant No. 51672087, the Science and Technology Program of Guangzhou City of China under Grant No. 201508020017 and the Fundamental Research Funds for the Central Universities.

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  1. These authors contributed equally: Tingting Wu, Shue Yang.

Authors and Affiliations

  1. Institute of Orthopedic Diseases and Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510630, P.R. China

    Tingting Wu

  2. National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, P.R. China

    Tingting Wu, Shue Yang & Jiandong Ye

  3. School of Materials Science and Engineering South, China University of Technology, Guangzhou, 510640, P.R. China

    Shue Yang & Jiandong Ye

  4. College of Chemistry and Materials, Jinan University, Guangzhou, 510632, P.R. China

    Haishan Shi

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  1. Tingting Wu
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Correspondence to Jiandong Ye.

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Wu, T., Yang, S., Shi, H. et al. Preparation and cytocompatibility of a novel bismuth aluminate/calcium phosphate cement with high radiopacity. J Mater Sci: Mater Med 29, 149 (2018). https://doi.org/10.1007/s10856-018-6154-1

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