Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications

  • Qaisar Nawaz
  • Muhammad Atiq Ur Rehman
  • Andreas Burkovski
  • Jochen Schmidt
  • Ana M. Beltrán
  • Ameen Shahid
  • Nina K. Alber
  • Wolfgang Peukert
  • Aldo R. BoccacciniEmail author
Special Issue: ESB 2017 Original Research
Part of the following topical collections:
  1. Special Issue: ESB 2017


Mesoporous bioactive glass (BG) nanoparticles based in the system: SiO2–P2O5–CaO–MnO were synthesized via a modified Stöber process at various concentrations of Mn (0–7 mol %). The synthesized manganese-doped BG nanoparticles were characterized in terms of morphology, composition, in vitro bioactivity and antibacterial activity. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Brunauer–Emmett–Teller (BET) analysis confirmed that the particles had spherical morphology (mean particle size: 110 nm) with disordered mesoporous structure. Energy dispersive X-ray spectroscopy (EDX) confirmed the presence of Mn, Ca, Si and P in the synthesized Mn-doped BG particles. Moreover, X-ray diffraction (XRD) analysis showed that Mn has been incorporated in the amorphous silica network (bioactive glass). Moreover, it was found that manganese-doped BG particles form apatite crystals upon immersion in simulated body fluid (SBF). Inductively coupled plasma atomic emission spectroscopy (ICP-OES) measurements confirmed that Mn is released in a sustained manner, which provided antibacterial effect against Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. The results indicate that the incorporation of Mn in the bioactive glass network is an effective strategy to develop novel multifunctional BG nanoparticles for bone tissue engineering.



QN would like to thank Higher Education Commission (HEC) of Pakistan for granting a scholarship. Authors would like to thank the TEM facilities of CITIUS-US. TEM analyses have been funded by Grant P2017/837 from the University of Seville (Spain).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Authors and Affiliations

  • Qaisar Nawaz
    • 1
  • Muhammad Atiq Ur Rehman
    • 1
  • Andreas Burkovski
    • 2
  • Jochen Schmidt
    • 3
  • Ana M. Beltrán
    • 4
  • Ameen Shahid
    • 5
  • Nina K. Alber
    • 2
  • Wolfgang Peukert
    • 3
  • Aldo R. Boccaccini
    • 1
    Email author
  1. 1.Department of Materials Science and Engineering, Institute of BiomaterialsUniversity of Erlangen-NurembergErlangenGermany
  2. 2.Microbiology DivisionUniversity of Erlangen-NurembergErlangenGermany
  3. 3.Institute of Particle TechnologyUniversity of Erlangen-NurembergErlangenGermany
  4. 4.Department of Materials Science and EngineeringUniversity of SevilleSevilleSpain
  5. 5.Institute of Chemical Reaction EngineeringUniversity of Erlangen-NurembergErlangenGermany

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