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Еlectrospun сellulose acetate membranes decorated with curcumin-PVP particles: preparation, antibacterial and antitumor activities

  • Biomaterials Synthesis and Characterization
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Abstract

Curcumin (Curc) exhibits anti-inflammatory, antibacterial and antitumor activity. However, its clinical application is limited by its poor bioavailability related to its extremely low water solubility. Novel materials allowing enhanced release of Curc in aqueous medium were obtained. The new materials consisted of electrospun fibers from cellulose acetate (CA) (mean fiber diameter ca. 780 nm ± 110 nm) with electrosprayed Curc/polyvinylpyrrolidone (Curc/PVP) particles. Scanning electron microscopy (SEM) showed that separated and evenly distributed particles of Curc/PVP were deposited on the surface of the mats and on the inner layers of the mat. X-ray diffraction studies showed that Curc was in amorphous state. In vitro studies demonstrated that Curc release was facilitated from Curc/PVP-on-CA mats (ca. 78% for 24 h) compared with the materials in which Curc was incorporated in CA fibers (17% for 24 h). Moreover, the curcumin-containing materials exhibited antibacterial activity against Gram-positive bacteria Staphylococcus aureus (S. aureus) and Gram-negative bacteria Escherichia coli (E. coli). Curc/PVP-on-CA fibrous mats exhibited high in vitro cytotoxicity towards HeLa tumor cells. Therefore, the obtained materials are promising for antibacterial wound dressing applications as well as for application in local treatment of cervical tumors.

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Acknowledgements

The authors thank the National Science Fund of Bulgaria for the financial support (Grant number DFNI–T02/1-2014).

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Authors and Affiliations

  1. Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 103A, Sofia, BG-1113, Bulgaria

    Petya Tsekova, Mariya Spasova, Nevena Manolova & Iliya Rashkov

  2. Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 26, Sofia, BG-1113, Bulgaria

    Nadya Markova

  3. Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev St, bl. 25, Sofia, BG-1113, Bulgaria

    Ani Georgieva & Reneta Toshkova

Authors
  1. Petya Tsekova
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  2. Mariya Spasova
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  3. Nevena Manolova
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Correspondence to Nevena Manolova.

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Tsekova, P., Spasova, M., Manolova, N. et al. Еlectrospun сellulose acetate membranes decorated with curcumin-PVP particles: preparation, antibacterial and antitumor activities. J Mater Sci: Mater Med 29, 9 (2018). https://doi.org/10.1007/s10856-017-6014-4

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  • DOI: https://doi.org/10.1007/s10856-017-6014-4

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