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Preparation of electrospun polyurethane nanofiber mats for the release of doxorubicine

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Abstract

Polyurethane (PU) and doxorubicine loaded-PU nanofiber mats were prepared by the electrospinning technique. The effect of some system and process parameters including flow rate, distance from collector, and concentration of solution on the size and morphology of nanofibers was investigated. The size, morphology and drug content of nanofiber mats were followed by scanning electron microscopy (SEM). FTIR and TGA methods were used for structural and thermal characterization, and DSC was also used for determining the form of drug within nanofiber mat. Doxorubicine release kinetics were studied in two different pHs (4.5 and 7.5) for two drug content and it was observed that there is an inverse correlation between the amounts of drug loaded and released.

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References

  1. Liang D, Hsiao BS, Chu B. Functional electrospun nanofibrous scaffolds for biomedical applications. Adv Drug Deliv. 2007;59:1392–412.

    Article  Google Scholar 

  2. Lee KB, Yoon KR, Woo SI, Choi IS. Surface modification of poly(glycolic acid) (PGA) for biomedical applications. J Pharm Sci. 2003;92:933–7.

    Article  Google Scholar 

  3. Tyler B, Gullotti D, Mangraviti A, Utusuki T, Brem H. Polylactic acid (PLA) controlled delivery carriers for biomedical applications. Adv Drug Deliv Rev. 2016;107:163–75.

    Article  Google Scholar 

  4. Suwantong O. Biomedical applications of electrospun polycaprolactone fiber mats. Polym Adv Tech. 2016;27:1264–73.

    Article  Google Scholar 

  5. Burke A, Hasırcı N. Polyurethanes in biomedical applications. In: Hasırcı N, Hasırcı V, editors. Advances in experimental medicine and biology. Boston, MA: Springer; 2004. Vol. 553.

  6. Wan W, Bannerman AD, Yang L, Mak H. Poly(vinyl alcohol) cryogels for biomedical applications. In: Okay O, editor. Polymeric cryogels. Boston, MA: Springer; 2014.

  7. Kim J, Choi SY, Kim KM, Lee CH, Park HS, Hwang SS, Hong SM, Kwak S, Yoo HO. Synthesis of PEO-based materials for biomedical applications. Macromol Symp. 2006;245-6:565–70.

    Article  Google Scholar 

  8. Devine DM, Devery SM, Lyons JG, Geever LM, Kennedy JE, Higginbotham CL. Multifunctional polyvinylpyrrolidinone-polyacrylic acid copolymer hydrogels for biomedical applications. Int J Pharm. 2006;326:50–9.

    Article  Google Scholar 

  9. Yang TH. Recent applications of polyacrylamide as biomaterials. Recent Pat Mater Sci. 2008;1:29–40.

    Article  Google Scholar 

  10. Boland ED, Coleman BD, Barnes CP, Simpson DG, Wnek GE, Bowlin GL. Electrospinning polydioxanone for biomedical applications. Acta Biomater. 2005;1:115–23.

    Article  Google Scholar 

  11. Andrianov AK (ed.). Polyphosphazenes for biomedical applications. John Wiley & Sons; 2009.

  12. Engels HW, Pirkl HG, Albers R, Albach RW, Krause J, Hoffmann A, Casselmann H, Dormish J. Polyurethanes: versatile materials and sustainable problem solvers for today’s challenges. Angew Chem Int Ed. 2013;52:9422–41.

    Article  Google Scholar 

  13. Rockwood DN, Woodhouse KA, Fromstein JD, Chase DB, Rabolt JF. Characterization of biodegradable polyurethane microfibers for tissue engineering. J Biomater Sci. 2007;18:743–58.

    Article  Google Scholar 

  14. Zdrahala RJ, Zdrahala IJ. Biomedical applications of polyurethanes: a review of past promises, present realities, and a vibrant future. J Biomater Appl. 1999;14:67–90.

    Article  Google Scholar 

  15. Sheikh FA, Barakat NAM, Kanjwal MA, Chaudhari AA, Jung IH, Lee JH, Kim HY. Electrospun antimicrobial polyurethane nanofibers containing silver nanoparticles for biotechnological applications. Macromol Res. 2009;17:688–96.

    Article  Google Scholar 

  16. Lionelli GT, Lawrence WT. Wound dressing. Surg Clin North Am. 2003;83:617–38.

    Article  Google Scholar 

  17. Thomas S. Wound management and dressings. Pharm P. 1990;1:37–57.

    Google Scholar 

  18. Bhardwaj N, Kundu SC. Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv. 2010;28:325–47.

    Article  Google Scholar 

  19. Khil MS, Cha DI, Kim HY, Kim IS, Bhattarai N. Electrospun nanofibrous poly-urethane membrane as wound dressing. J Biomed Mater Res B. 2003;67:675–9.

  20. Huang ZM, Zhang YZ, Kotaki M, Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol. 2003;63:2223–53.

    Article  Google Scholar 

  21. Verreck G, Chun I, Peeters J, Rosenblatt J, Brewster ME. Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning. Pharm Res. 2003;20:810–7.

    Article  Google Scholar 

  22. Thompson CJ, Chase GG, Yarin AL, Reneker DH. Effects of parameters on nanofiber diameter determined from electrospinning model. Polymer. 2007;48:6913–22.

    Article  Google Scholar 

  23. Yuan X, Zhang Y, Dong C, Sheng J. Morphology of ultrafine polysulfone fibers prepared by electrospinning. Polym Int. 2004;53:1704–10.

    Article  Google Scholar 

  24. Haghi AK, Akbari M. Trends in electrospinning of natural nanofibers. Phys Status Solid A. 2007;204:1830–4.

    Article  Google Scholar 

  25. Megelski S, Stephens JS, Chase DB, Rabolt JF. Micro- and nanostructured surface morphology on electrospun polymer fibers. Macromolecules. 2002;35:8456–66.

    Article  Google Scholar 

  26. Zong X, Kim K, Fang D, Ran S, Hsiao BS, Chu B. Structure and process relationship of electrospun bioadsorbable nanofiber membrane. Polymer. 2002;439:4403–12.

    Article  Google Scholar 

  27. Doshi J, Reneker DH. Electrospinning process and application of electrospun fibers. J Electro. 1995;35:151–6.

    Article  Google Scholar 

  28. Geng X, Kwon OH, Jang J. Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials. 2005;26:5427–32.

    Article  Google Scholar 

  29. Lee JS, Choi KH, Ghim HD, Kim SS, Chun DH, Kim HY. Role of molecular weight of atactic poly (vinyl alcohol) (PVA) in the structure and properties of PVA nanofabric prepared by electrospinning. J Appl Polym Sci. 2004;93:1638–46.

    Article  Google Scholar 

  30. Trovati GT, Sanches EA, Neto SC, Mascarenhas YP, Chierice GO. Characterization of poly-urethane resins by FTIR, TGA, and XRD. J Appl Polym Sci. 2010;115:263–8.

    Article  Google Scholar 

  31. Manocha B, Margaritis A. Controlled release of doxorubicin from doxorubicin/γ-polyglutamic acid ionic complex. J Nanomater. 2010; Article ID 780171:1–9.

  32. Teicher BA. Cancer drug resistance. Totowa, NJ: Humana Press Inc.; 2006.

    Book  Google Scholar 

  33. Yu H, Jia Y, Yao C, Lu Y. PCL/PEG core/sheath fibers with controlled drug release rate fabricated on the basis of a novel combined technique. Int J Pharm. 2014;469:17–22.

    Article  Google Scholar 

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Acknowledgements

This study was carried out in accordance with the Chemistry Department, Hacettepe University (Ankara, Turkey). The support of the HU Scientific Research Foundation through the HU-BAB-011D10601001 and HU-BAB-012D06601014 projects are gratefully acknowledged.

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Authors and Affiliations

  1. Faculty of Science, Department of Chemistry, Hacettepe University, 06800 Beytepe, Ankara, Turkey

    Esra Kiliç & Nursel Pekel Bayramgil

  2. Department of Chemical Engineering, Afyon Kocatepe University, 03200, Afyonkarahisar, Turkey

    Arzu Yakar

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  1. Esra Kiliç
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  2. Arzu Yakar
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  3. Nursel Pekel Bayramgil
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Correspondence to Nursel Pekel Bayramgil.

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Kiliç, E., Yakar, A. & Pekel Bayramgil, N. Preparation of electrospun polyurethane nanofiber mats for the release of doxorubicine . J Mater Sci: Mater Med 29, 8 (2018). https://doi.org/10.1007/s10856-017-6013-5

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