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Influence of acid treatment on surface properties and in vivo performance of Ti6Al4V alloy for biomedical applications

  • Clinical Applications of Biomaterials
  • Original Research
  • Published:
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Abstract

The purpose of this work was to investigate the influence of acid treatment on the surface properties and in vivo performance of titanium grade 5 (Ti6Al4V) alloy. Mini-implants with surface treatment were inserted into New Zealand rabbit tibia for 1, 4 and 8 weeks. SEM analysis showed intercommunicated micropores in acid treated samples. AFM showed micron and sub-micron roughness. The thickness of the titanium oxide layer increased with surface treatment, with a significant reduction of Al and V concentration. Acid treated implant removal torque was larger than without treatment. The implants/bone interface of acid treated implants showed dense adhered Ca/P particles with spreading osteoblasts after 4 weeks and newly formed bone trabeculae after 8 weeks. Analysis of rabbit blood that received treated implant showed lower Al and V contents at all times. Acid treatment improved surface morphology and mechanical stability, which allowed initial events of osseointegration, while Al-V ion release was reduced.

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Acknowledgements

We thank Carlos Eduardo Caetano and Domingos Peçanha (Laboratory of Experimental Surgery) for the surgical support and animal care during the experimental period; Prof Marc A. Meyers (University of California) for support on the preparation of histological displays, Prof Raphael Hirata (Microbiology Laboratory- Universidade do Estado do Rio de Janeiro) for help with the blood sample preparations for atomic absorption spectrometry; and Prof Ronaldo de Biase for the revision of the manuscript. This research was supported by the grants E-26/102.766/2012, BEX 539012-5/2013, Universal 476757/2012-6, E-26/201.759/2015, E-26/201.828/2015, E-26/010.001.262/2015 and 449472-2014-0.

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Authors and Affiliations

  1. Biomaterials Laboratory, Instituto Militar de Engenharia, Rio de Janeiro, RJ, 2290-270, Brazil

    Daniel J. Fernandes & Carlos N. Elias

  2. Laboratory of Experimental Surgery, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, 20561-030, Brazil

    Ruy G. Marques

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  1. Daniel J. Fernandes
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Correspondence to Daniel J. Fernandes.

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Fernandes, D.J., Marques, R.G. & Elias, C.N. Influence of acid treatment on surface properties and in vivo performance of Ti6Al4V alloy for biomedical applications. J Mater Sci: Mater Med 28, 164 (2017). https://doi.org/10.1007/s10856-017-5977-5

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