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TiO2-containing and ZnO-containing borosilicate glass—a novel thin glass with exceptional antibiofilm performances to prevent microfouling

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

Biofilm formation, also known as microfouling, on indwelling medical devices such as catheters or prosthetic joints causes difficult to treat and recurrent infections. It is also the initial step for biocorrosion of surfaces in aquatic environment. An efficient prevention of microfouling is preferable but the development of antibiofilm surfaces is enormously challenging. Therefore, soda-lime, aluminosilicate, and three borosilicate glasses with different TiO2 and ZnO compositions were investigated on their feasibility to prevent biofilm formation by standardized in vitro biofilm assays using different pathogenic bacteria. Furthermore, the biocompatibility of these glasses was evaluated using eukaryotic cell lines end erythrocytes. Only two borosilicate glasses, containing TiO2 and ZnO, showed an increased antibiofilm performance inhibiting biofilm adhesion and formation. The biofilm thickness and area were significantly reduced by over 90 % and characterized by diffuse structures. All tested glass types showed neither cytotoxicity nor hemotoxicity. Therefore, the antibiofilm borosilicate-thin glasses are qualified for surface coatings where biofilms are not desirable such as on medical devices.

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Acknowledgments

The authors thank the Department of Research and Technology Development of SCHOTT AG (Mainz) for the collaboration and for provision of the glass slides. This work was supported by a grant from the Federal Ministry of Education and Research (Germany), grant numbers 01EO1002.

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Authors and Affiliations

  1. Center for Infectious Diseases and Infection Control, Jena University Hospital, Jena, 07747, Germany

    Mareike Klinger-Strobel, Oliwia Makarewicz & Mathias W. Pletz

  2. Center for Sepsis Control and Care, Jena University Hospital, Jena, 07747, Germany

    Mareike Klinger-Strobel, Oliwia Makarewicz, Mathias W. Pletz, Andreas Stallmach & Christian Lautenschläger

  3. Department of Internal Medicine IV, Jena University Hospital, Jena, 07747, Germany

    Andreas Stallmach & Christian Lautenschläger

Authors
  1. Mareike Klinger-Strobel
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  2. Oliwia Makarewicz
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Correspondence to Mareike Klinger-Strobel.

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Klinger-Strobel, M., Makarewicz, O., Pletz, M.W. et al. TiO2-containing and ZnO-containing borosilicate glass—a novel thin glass with exceptional antibiofilm performances to prevent microfouling. J Mater Sci: Mater Med 27, 175 (2016). https://doi.org/10.1007/s10856-016-5792-4

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  • DOI: https://doi.org/10.1007/s10856-016-5792-4

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