CeF3-ZnO scintillating nanocomposite for self-lighted photodynamic therapy of cancer
- 446 Downloads
We report on the synthesis and characterization of a composite nanostructure based on the coupling of cerium fluoride (CeF3) and zinc oxide (ZnO) for applications in self-lighted photodynamic therapy. Self-lighted photodynamic therapy is a novel approach for the treatment of deep cancers by low doses of X-rays. CeF3 is an efficient scintillator: when illuminated by X-rays it emits UV light by fluorescence at 325 nm. In this work, we simulate this effect by exciting directly CeF3 fluorescence by UV radiation. ZnO is photo-activated in cascade, to produce reactive oxygen species. This effect was recently demonstrated in a physical mixture of distinct nanoparticles of CeF3 and ZnO [Radiat. Meas. (2013) 59:139–143]. Oxide surface provides a platform for rational functionalization, e.g., by targeting molecules for specific tumors. Our composite nanostructure is stable in aqueous media with excellent optical coupling between the two components; we characterize its uptake and its good cell viability, with very low intrinsic cytotoxicity in dark.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
- 11.SOSG kit, produced by Molecular Probes and commercialized by Life Technologies, product information: “Singlet Oxyg. Sens. Green Reagent”, Revis. 30/01/2004, http://tools.lifetechnologies.com/content/sfs/manuals/mp36002.pdf. Accessed 2 May 2016.