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Microstructure-modified biodegradable magnesium alloy for promoting cytocompatibility and wound healing in vitro

  • Da-Jun Lin
  • Fei-Yi Hung
  • Ming-Long Yeh
  • Truan-Sheng Lui
Biocompatibility Studies Original Research
Part of the following topical collections:
  1. Biocompatibility Studies

Abstract

The microstructure of biomedical magnesium alloys has great influence on anti-corrosion performance and biocompatibility. In practical application and for the purpose of microstructure modification, heat treatments were chosen to provide widely varying microstructures. The aim of the present work was to investigate the influence of the microstructural parameters of an Al-free Mg–Zn–Zr alloy (ZK60), and the corresponding heat-treatment-modified microstructures on the resultant corrosion resistance and biological performance. Significant enhancement in corrosion resistance was obtained in Al-free Mg–Zn–Zr alloy (ZK60) through 400 °C solid-solution heat treatment. It was found that the optimal condition of solid-solution treatment homogenized the matrix and eliminated internal defects; after which, the problem of unfavorable corrosion behavior was improved. Further, it was also found that the Mg ion-release concentration from the modified ZK60 significantly induced the cellular activity of fibroblast cells, revealing in high viability value and migration ability. The experimental evidence suggests that this system can further accelerate wound healing. From the perspective of specific biomedical applications, this research result suggests that the heat treatment should be applied in order to improve the biological performance.

Keywords

Corrosion Resistance Magnesium Alloy Corrosion Current Density Bimodal Microstructure Anticorrosion Performance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors are grateful to The Instrument Center of National Cheng Kung University and Ministry of Science and Technology, 103-2221-E-006-066 for the financial support of this research.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Da-Jun Lin
    • 1
  • Fei-Yi Hung
    • 1
  • Ming-Long Yeh
    • 2
  • Truan-Sheng Lui
    • 1
  1. 1.Department of Materials Science and EngineeringNational Cheng Kung UniversityTainanTaiwan
  2. 2.Department of Biomedical EngineeringNational Cheng Kung UniversityTainanTaiwan

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