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Inhibition of pathogenic bacterial growth on excision wound by green synthesized copper oxide nanoparticles leads to accelerated wound healing activity in Wistar Albino rats


An impaired wound healing is one of the major health related problem in diabetic and non-diabetic patients around the globe. The pathogenic bacteria play a predominant role in delayed wound healing, owing to interaction in the wound area. In our previous work we developed green chemistry mediated copper oxide nanoparticles using Ficus religiosa leaf extract. In the present study we make an attempt to evaluate the anti-bacterial, and wound healing activity of green synthesized copper oxide nanoparticles in male Wistar Albino rats. The agar well diffusion assay revealed copper oxide nanoparticles have substantial inhibition activity against human pathogenic strains such as Klebsiella pneumoniae, Shigella dysenteriae, Staphylococcus aureus, Salmonella typhimurium and Escherichia coli, which were responsible for delayed wound healing process. Furthermore, the analyses results of wound closure, histopathology and protein profiling confirmed that the F. religiosa leaf extract tailored copper oxide nanoparticles have enhanced wound healing activity in Wistar Albino rats.

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We are grateful to the Department of Science and Technology (DST) for providing the financial assistance to Mr. Renu Sankar through the INSPIRE Fellowship. We extend our acknowledgement to the University Grant Commission (UGC) and the Science & Engineering Research Board (SERB) for their financial support. We also thank the Department of Science and Technology-Fund for Improvement of S & T Infrastructure in Universities and Higher Educational Institutions (DST-FIST) for their infrastructure support to our department.

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Correspondence to Kanchi Subramanian Shivashangari or Vilwanathan Ravikumar.

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Sankar, R., Baskaran, A., Shivashangari, K.S. et al. Inhibition of pathogenic bacterial growth on excision wound by green synthesized copper oxide nanoparticles leads to accelerated wound healing activity in Wistar Albino rats. J Mater Sci: Mater Med 26, 214 (2015).

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  • Metal Oxide Nanoparticles
  • Wound Contraction
  • Shigella Dysenteriae
  • Excision Wound
  • Copper Oxide Nanoparticles