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Biodegradable fibre scaffolds incorporating water-soluble drugs and proteins

  • Biomaterials Synthesis and Characterization
  • Original Research
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Abstract

A new type of biodegradable drug-loaded fibre scaffold has been successfully produced for the benefit of water-soluble drugs and proteins. Model drug loaded calcium carbonate (CaCO3) microparticles incorporated into poly(lactic acid-co-glycolic acid) (PLGA) fibres were manufactured by co-precipitation of CaCO3 and the drug molecules, followed by electrospinning of a suspension of such drug-loaded microparticles in a PLGA solution. Rhodamine 6G and bovine serum albumin were used as model drugs for our release study, representing small bioactive molecules and protein, respectively. A bead and string structure of fibres was achieved. The drug release was investigated with different drug loadings and in different pH release mediums. Results showed that a slow and sustained drug release was achieved in 40 days and the CaCO3 microparticles used as the second barrier restrained the initial burst release.

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Authors and Affiliations

  1. School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK

    J. Ma, T. Peijs & G. B. Sukhorukov

  2. Department of Materials, Oxford University Begbroke Science Park, Sandy Lane, Yarnton, Kidlington, OX5 1PF, UK

    J. Meng

  3. Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands

    M. Simonet

  4. Department of Materials, Imperial College London, London, SW7 2AZ, UK

    N. Stingelin

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  1. J. Ma
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  2. J. Meng
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  3. M. Simonet
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  4. N. Stingelin
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  6. G. B. Sukhorukov
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Correspondence to T. Peijs.

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Ma, J., Meng, J., Simonet, M. et al. Biodegradable fibre scaffolds incorporating water-soluble drugs and proteins. J Mater Sci: Mater Med 26, 205 (2015). https://doi.org/10.1007/s10856-015-5537-9

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  • DOI: https://doi.org/10.1007/s10856-015-5537-9

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