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Biomaterial science meets computational biology

  • Special Issue: ESB 2014
  • Biomaterials Synthesis and Characterisation
  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell–cell and cell–niche interactions.

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Authors and Affiliations

  1. Faculty of Science and Engineering, Queensland University of Technology, Brisbane, Australia

    Dietmar W. Hutmacher, J. Paige Little & Graeme J. Pettet

  2. Faculty of Health, Queensland University of Technology, Brisbane, Australia

    Dietmar W. Hutmacher & Daniela Loessner

  3. Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD, 4059, Australia

    Dietmar W. Hutmacher, J. Paige Little, Graeme J. Pettet & Daniela Loessner

  4. Institute for Advanced Study, Technical University of Munich, Munich, Germany

    Dietmar W. Hutmacher

  5. Institute for Future Environments, Queensland University of Technology, Brisbane, Australia

    Graeme J. Pettet

  6. Translational Research Institute, Brisbane, Australia

    Daniela Loessner

Authors
  1. Dietmar W. Hutmacher
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  2. J. Paige Little
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  3. Graeme J. Pettet
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  4. Daniela Loessner
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Corresponding authors

Correspondence to Dietmar W. Hutmacher or Daniela Loessner.

Additional information

Dietmar W. Hutmacher and J. Paige Little are joint first authors.

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Hutmacher, D.W., Little, J.P., Pettet, G.J. et al. Biomaterial science meets computational biology. J Mater Sci: Mater Med 26, 185 (2015). https://doi.org/10.1007/s10856-015-5518-z

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  • DOI: https://doi.org/10.1007/s10856-015-5518-z

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