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Atmospheric pressure plasma CVD as a tool to functionalise wound dressings

  • Engineering and Nano-engineering Approaches for Medical Devices
  • Published:
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Abstract

The main goal of this investigation was the preparation of an antibacterial layer system for additional modification of wound dressings with atmospheric plasma. Furthermore, the modified wound dressings were checked on there bactericidal and cytotoxic activity. The layer system was applied by using a novel atmospheric pressure plasma chemical vapour deposition technique on a variety of textile substrates which are suitable as wound dressing materials. The layer system composed of silicon dioxide with in situ generated embedded silver nanoparticles. The bactericidal activity of the produced wound dressings was investigated against different bacteria like Staphylococcus aureus and Klebsiella pneumoniae while the cytotoxic potential of the coated wound dressings was verified using human keratinocytes. Even at low concentrations of silver precursor a strong antibacterial effect was observed in direct contact with S. aureus and K. pneumoniae. Furthermore, extractions produced from the coated textiles showed a good antibacterial effect. By means of optimised coating parameters a therapeutic window for those wound dressings could be identified. Consequently, the atmospheric pressure plasma chemical vapour deposition technique promise an effective and low cost modification of wound dressing materials.

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Acknowledgements

The authors gratefully acknowledge the assistance by the laboratory team of the Department of Dermatology from the University Medical Center Jena and Dr. Martina Schweder for SEM/EDX measurements. This work was partially financially supported by the German BMBF under Grant Number 03WKBR11Z.

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Authors and Affiliations

  1. Innovent e.V., Pruessingstraße 27B, 07745, Jena, Germany

    Sebastian Spange, Andreas Pfuch, Oliver Beier & Bernd Grünler

  2. Department of Dermatology, University Medical Center Jena, Erfurter Strasse 35, 07743, Jena, Germany

    Cornelia Wiegand & Uta C. Hipler

Authors
  1. Sebastian Spange
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  2. Andreas Pfuch
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  3. Cornelia Wiegand
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  4. Oliver Beier
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  5. Uta C. Hipler
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  6. Bernd Grünler
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Correspondence to Sebastian Spange.

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Spange, S., Pfuch, A., Wiegand, C. et al. Atmospheric pressure plasma CVD as a tool to functionalise wound dressings. J Mater Sci: Mater Med 26, 76 (2015). https://doi.org/10.1007/s10856-015-5417-3

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  • DOI: https://doi.org/10.1007/s10856-015-5417-3

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