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Upon some multi-membrane hydrogels based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) Undecane): preparation, characterization and in vivo tests

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Abstract

The study presents the possibility of preparation of multi-membrane gel systems with different morphologies and properties, based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) undecane) copolymer and crosslinked with N,N′-methylene-bis-acrylamide. The basic copolymer has dual thermo- and pH sensitive character. After the core hydrogel is realized, the preformed gel is immersed in the aqueous solutions of ammonia, sodium chloride and sodium citrate for further edge constructing of the supramolecular assemblies. Then, the new layers by adding new sets of gelifying components are realized. The new multi-membrane gel systems are intended to be used as matrix for bioactive substances embedding. In this context the systems were loaded with norfloxacin as drug model. The in vivo tests show good biocompatibility for the implants based on multi-membrane gel structures loaded with drug.

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Acknowledgments

This work was financially supported by the Grant of the Romanian National Authority for Scientific Research, CNCS-UEFISCDI, Project Number PN-II-211/2012’’Interdisciplinary research on multifunctional hybrid particles for bio-requirements”.

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Authors and Affiliations

  1. “Petru Poni” Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley No. 41-A, 700487, Iasi, Romania

    Loredana E. Nita, Aurica P. Chiriac & Manuela T. Nistor

  2. Gr. T. Popa University of Medicine and Pharmacy, Universitatii Street No. 16, 700115, Iasi, Romania

    Liliana Tartau

Authors
  1. Loredana E. Nita
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  2. Aurica P. Chiriac
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  3. Manuela T. Nistor
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  4. Liliana Tartau
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Correspondence to Loredana E. Nita.

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Paper dedicated to the 65th anniversary of “Petru Poni” Institute of Macromolecular Chemistry of Romanian Academy, Iasi, Romania.

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Nita, L.E., Chiriac, A.P., Nistor, M.T. et al. Upon some multi-membrane hydrogels based on poly(N,N-dimethyl-acrylamide-co-3,9-divinyl-2,4,8,10-tetraoxaspiro (5.5) Undecane): preparation, characterization and in vivo tests. J Mater Sci: Mater Med 25, 1757–1768 (2014). https://doi.org/10.1007/s10856-014-5205-5

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  • DOI: https://doi.org/10.1007/s10856-014-5205-5

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