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Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals

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Abstract

Bioactive glass has been shown to stimulate bone regeneration and soft tissue healing. In this study, we evaluated the local protective effects of bioactive glass on experimental gastric ulcers, in comparison with omeprazole and hydrotalcite. Single and multiple gavage of 45S5 bioactive glass dose-dependently protected stress ulcers in mice and chronic ulcers in rats. Multi-daily gavage of bioactive glass for 7 days prevented chronic ulcer recurrence by 50 %. Bioactive glass ionic dissolution produced marked proliferation of ethanol-injured GES-1 human gastric mucosa epithelial cells 48 and 72 h after exposure. Bioactive glass was shown to be hardly absorbed after single or multi-daily gavage. This study, for the first time, demonstrates that bioactive glass is effective in protecting against gastric ulcers, with its high efficacy comparable to omeprazole and superior to hydrotalcite. The lack of oral absorption makes bioactive glass a potential for treatment of peptic ulcers omitting systemic toxicity or side-effects.

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References

  1. Laine L, Takeuchi K, Tarnawski A. Gastric mucosal defense and cytoprotection: bench to bedside. Gastroenterology. 2008;135(1):41–60.

    Article  CAS  Google Scholar 

  2. Szabo S. Mechanisms of gastric mucosal injury and protection. J Clin Gastroenterol. 1991;13(Suppl 2):S21–34.

    Google Scholar 

  3. Walan A. Clinical experience with omeprazole: assessment of efficacy and safety. J Gastroenterol Hepatol. 1989;4(Suppl 2):27–33.

    Google Scholar 

  4. Holtermuller KH, Liszkay M, Bernard I, Haase W. Therapie des Ulcus ventriculi–Ein Vergleich zwischen dem niedrig dosierten Antazidum Hydrotalcit und Ranitidin–Ergebnisse einer randomisierten multizentrischen Doppelblindstudie. Talcivent Studiengruppe. Z Gastroenterol. 1992;30(10):717–21.

    CAS  Google Scholar 

  5. Tarnawski AS, Tomikawa M, Ohta M, Sarfeh IJ. Antacid talcid activates in gastric mucosa genes encoding for EGF and its receptor. The molecular basis for its ulcer healing action. J Physiol Paris. 2000;94(2):93–8.

    Article  CAS  Google Scholar 

  6. Hench LL, Splinter RJ, Allen WC, Greenlee TK. Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res. 1971;5(6):117–41.

    Article  Google Scholar 

  7. Hu YC, Zhong JP. Osteostimulation of bioglass. Chin Med J (Engl). 2009;122(19):2386–9.

    Google Scholar 

  8. Jones JR, Lin S, Yue S, Lee PD, Hanna JV, Smith ME, et al. Bioactive glass scaffolds for bone regeneration and their hierarchical characterisation. Proc Inst Mech Eng H. 2010;224(12):1373–87.

    Article  CAS  Google Scholar 

  9. Gosain AK. Bioactive glass for bone replacement in craniomaxillo facial reconstruction. Plast Reconstr Surg. 2004;114(2):590–3.

    Article  Google Scholar 

  10. Ilharreborde B, Morel E, Fitoussi F, Presedo A, Souchet P, Penneçot GF, et al. Bioactive glass as bone substitute for spine fusion in adolescent idiopathic scoliosis. J Pediatr Orthop. 2008;28:347–51.

    Article  Google Scholar 

  11. Gillette RL, Swaim SF, Sartin EA, Bradley DM, Coolman SL. Effects of a bioactive glass on healing of closed skin wounds in dogs. Am J Vet Res. 2001;62(7):1149–53.

    Article  CAS  Google Scholar 

  12. Allan I, Newman H, Wilson M. Antibacterial activity of particulate bioglass against supra- and subgingival bacteria. Biomaterials. 2001;22(12):1683–7.

    Article  CAS  Google Scholar 

  13. Hu S, Chang J, Liu M, Ning C. Study on antibacterial effect of 45S5 bioglass. J Mater Sci Mater Med. 2009;20(1):281–6.

    Article  CAS  Google Scholar 

  14. Koller G, Roether J, Bruce K, Deb S. Antimicrobial potential of bioactive bone cements. J Appl Biomater Biomech. 2008;6(1):16–22.

    CAS  Google Scholar 

  15. Rectenwald JE, Minter RM, Rosenberg JJ, Gaines GC, Lee S, Moldawer LL. Bioglass attenuates a proinflammatory response in mouse peritoneal endotoxicosis. Shock. 2002;17(2):135–8.

    Article  Google Scholar 

  16. Wang Y, Ma B, Xia ZF, Tang HT, Wang GY, Liu Y. The efficacy of bioglass on wound repair of the 30 cases of burn patients. Chin J Burns. 2006;22:474.

    Google Scholar 

  17. Ogino M, Ohuchi H, Hench L. Compositional dependence of the formation of calcium phosphate film on bioglass®. J Biomed Mater Res. 1980;14:55–64.

    Article  CAS  Google Scholar 

  18. Kim C, Clark AE, Hench L. Early stages of calcium-phosphate layer formation in bioglasses. J Non Crystal Solids. 1988;113:195–202.

    Article  Google Scholar 

  19. Hench LL. Bioceramics: from concept to clinic. J Am Ceram Soc. 1991;74:1487–510.

    Article  CAS  Google Scholar 

  20. Zhong JP, Greenspan DC. Bioglass surface reactivity: from in vitro to in vivo. Bioceramics. 1998;11:415–8.

    CAS  Google Scholar 

  21. Zhong JP, Greenspan DC, Feng JW. A microstructural examination of apatite induced by bioglass in vitro. J Mater Sci Mater Med. 2002;13:321–6.

    Article  CAS  Google Scholar 

  22. Xynos ID, Edgar AJ, Buttery LD, Hench LL, Polak JM. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochem Biophysi Res Comm. 2000;276:461–5.

    Article  CAS  Google Scholar 

  23. Xynos ID, Edgar AJ, Buttery LD, Hench LL, Polak JM. Gene-expression profiling of human osteoblasts following treatment with the ionic products of bioglass 45S5 dissolution. J Biomed Mater Res. 2001;55(2):151–7.

    Article  CAS  Google Scholar 

  24. Watanabe T, Higuchi K, Tominaga K, Fujiwara Y, Arakawa T. Acid regulates inflammatory response in a rat model of induction of gastric ulcer recurrence by interleukin 1beta. Gut. 2001;48(6):774–81.

    Article  CAS  Google Scholar 

  25. Ma AN, Gong N, Lu JM, Huang JL, Hao B, Wang YX. The effect of bioglass 45S5 on prevention and treatment of experimental gastric ulcer. Chin J Pharmacol Toxicol. 2011;25(Suppl):115.

    Google Scholar 

  26. Wang ZB, Li JX, Zhu LQ, Niu FL, Cui W. Inhibiting effects of Panax notoginseng extracts on proliferation of GES-1 cells and MNNG-transformed GES-1 cells. Zhong Xi Yi Jie He Xue Bao. 2004;2(6):445–9.

    Article  Google Scholar 

  27. Hayase M, Takeuchi K. Gastric acid secretion and lesion formation in rats under water-immersion stress. Dig Dis Sci. 1986;31(2):166–71.

    Article  CAS  Google Scholar 

  28. Takagi K, Okabe S, Saziki R. A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing. Jpn J Pharmacol. 1969;19(3):418–26.

    Article  CAS  Google Scholar 

  29. Bullock S, Johnston EE, Willson T, Gatenholm P, Wynne KJ. Surface science of a filled polydimethylsiloxane-based alkoxysilane-cured elastomer: RTV11. J Colloid Interface Sci. 1999;210(1):18–36.

    Article  CAS  Google Scholar 

  30. Wang YX, Pang CC. Functional integrity of the central and sympathetic nervous systems is a prerequisite for pressor and tachycardic effects of diphenyleneiodonium, a novel inhibitor of nitric oxide synthase. J Pharmacol Exp Ther. 1993;265(1):263–72.

    CAS  Google Scholar 

  31. Giannoudis PV, Dinopoulos H, Tsiridis E. Bone substitutes: an update. Injury. 2005;36(Suppl 3):S20–7.

    Article  Google Scholar 

  32. Henke PG. Recent studies of the central nucleus of the amygdala and stress ulcers. Neurosci Biobehav Rev. 1988;12(2):143–50.

    Article  CAS  Google Scholar 

  33. Okabe S, Amagase K. An overview of acetic acid ulcer models and their utility for drug screening. Nippon Yakurigaku Zasshi. 2003;122(1):73–92.

    Article  CAS  Google Scholar 

  34. Day RM. Bioactive glass stimulates the secretion of angiogenic growth factors and angiogenesis in vitro. Tissue Eng. 2005;11(5–6):768–77.

    Article  CAS  Google Scholar 

  35. Jell G, Stevens MM. Gene activation by bioactive glasses. J Mater Sci Mater Med. 2006;17(11):997–1002.

    Article  CAS  Google Scholar 

  36. Asselin A, Hattar S, Oboeuf M, Greenspan D, Berdal A, Sautier JM. The modulation of tissue-specific gene expression in rat nasal chondrocyte cultures by bioactive glasses. Biomaterials. 2004;25(25):5621–30.

    Article  CAS  Google Scholar 

  37. Christodoulou I, Buttery LD, Saravanapavan P, Tai G, Hench LL, Polak JM. Dose- and time-dependent effect of bioactive gel-glass ionic-dissolution products on human fetal osteoblast-specific gene expression. J Biomed Mater Res B Appl Biomater. 2005;74(1):529–37.

    Google Scholar 

  38. Day R, Boccaccini AR, Shurey S, Roether JA, Forbes A, Hench LL, Gabe SM. Assessment of polyglycolic acid mesh and bioactive glass for soft tissue engineering scaffolds. Biomaterials. 2004;25(27):5857–66.

    Article  CAS  Google Scholar 

  39. Franko TG, Richter JE. Proton-pump inhibitors for gastric acid-related disease. Cleve Clin J Med. 1998;65(1):27–34.

    CAS  Google Scholar 

  40. Cundy T, Mackay J. Proton pump inhibitors and severe hypomagnesaemia. Curr Opin Gastroenterol. 2011;27(2):180–5.

    Article  CAS  Google Scholar 

  41. Kuipers MT, Thang HD, Arntzenius AB. Hypomagnesaemia due to use of proton pump inhibitors: a review. Neth J Med. 2009;67(5):169–72.

    CAS  Google Scholar 

  42. Gouraud A, Vochelle V, Descotes J, Vial T. Proton pump inhibitor-induced neutropenia: possible cross-reactivity between omeprazole and pantoprazole. Clin Drug Investig. 2010;30(8):559–63.

    Article  CAS  Google Scholar 

  43. Lindquist M, Edwards IR. Endocrine adverse effects of omeprazole. BMJ. 1992;305(6851):451–2.

    Article  CAS  Google Scholar 

  44. Carvajal A, Martin Arias LH. Gynecomastia and sexual disorders after the administration of omeprazole. Am J Gastroenterol. 1995;90(6):1028–9.

    CAS  Google Scholar 

  45. Carvajal A, Macias D, Gutierrez A, Ortega S, Sainz M, Martin Arias LH, et al. Gynaecomastia associated with proton pump inhibitors: a case series from the Spanish pharmacovigilance system. Drug Saf. 2007;30(6):527–31.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work is financially supported in part by Changzhou Beiersheng Biotech Co. Ltd, Changzhou, China.

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Authors and Affiliations

  1. School of Pharmacy, Shanghai Jiao Tong University, The No.6 Biomedicine Building (Suite 106) 800 Dongchuan Road, Shanghai, 200240, China

    Ai-niu Ma, Nian Gong, Jin-miao Lu, Jin-lu Huang, Bin Hao, Yang Guo, Yuhong Xu & Yong-xiang Wang

  2. Chinese Academy of Sciences, Shanghai Institute of Ceramics, Shanghai, 200050, China

    Jipin Zhong & Jiang Chang

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  1. Ai-niu Ma
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  2. Nian Gong
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  3. Jin-miao Lu
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Correspondence to Yong-xiang Wang.

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Ma, An., Gong, N., Lu, Jm. et al. Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals. J Mater Sci: Mater Med 24, 803–809 (2013). https://doi.org/10.1007/s10856-012-4844-7

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  • DOI: https://doi.org/10.1007/s10856-012-4844-7

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