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SEM and EDS investigation of a pyrolytic carbon covered C/C composite maxillofacial implant retrieved from the human body after 8 years

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Abstract

The long term effect of the human body on a pyrolytic carbon covered C/C composite maxillofacial implant (CarBulatTm) was investigated by comparing the structure, the surface morphology and composition of an implant retrieved after 8 years to a sterilized, but not implanted one. Although the thickness of the carbon fibres constituting the implants did not change during the 8 year period, the surface of the implant retrieved was covered with a thin surface layer not present on the unimplanted implant. The composition of this layer is identical to the composition of the underlying carbon fibres. Calcium can only be detected on the surface as a trace element implying that the new layer is not formed by bone tissue. Residual soft tissue penetrating the bulk material between the carbon fibre bunches was found on the retrieved implant indicating the importance of the surface morphology in tissue growth and adhering to implants.

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References

  1. Scholz M-S, Blanchfield JP, Bloom LD, Coburn BH, Elkington M, Fuller JD, Gilbert ME, Muflahi SA, Pernice MF, Rae SI, Trevarthen JA, White SC, Weaver PM, Bond IP. The use of composite materials in modern orthopaedic medicine and prosthetic devices: a review. Compos Sci Technol. 2011;71:1791–803.

    Article  CAS  Google Scholar 

  2. Golecki I. Rapid vapor-phase densification of refractory composites. Mat Sci Eng R. 1997;20:37–124.

    Article  Google Scholar 

  3. Jenkins DHR, Forster IW, McKibbin, Ralis ZA. Induction of tendon ligament formation by carbon implants. J Bone Joint Surg. (Br). 1977;59:53–7.

    CAS  Google Scholar 

  4. Adams D, Williams DF. The response of bone to carbon–carbon composites. Biomaterials. 1984;5:59–64.

    Article  CAS  Google Scholar 

  5. More N, Baquey C, Barthe X, Rouais F, Rivel J, Trinquecoste M, Marchand A. Biocompatibility of carbon–carbon materials: in vivo study of their erosion using 14carbon labelled samples. Biomaterials. 1988;9:328–34.

    Article  CAS  Google Scholar 

  6. Czajkowska B, Blazewicz M. Phagocytosis of chemically modified carbon materials. Biomaterials. 1997;18:69–74.

    Article  CAS  Google Scholar 

  7. Pesakova V, Klezl Z, Balik K, Adam M. Biomechanical and biological properties of the implant material carbon–carbon composite covered with pyrolytic carbon. J Mater Sci Mater Med. 2000;11:793–8.

    Article  CAS  Google Scholar 

  8. Blazewicz M. Carbon Materials in the treatment of soft and hard tissue injuries. Eur Cell Mater. 2001;2:21–9.

    CAS  Google Scholar 

  9. Stary V, Bacakova L, Horník J, Chmelík V. Bio-compatibility of the surface layer of pyrolytic graphite. Thin Solid Films. 2003;433:191–8.

    Article  CAS  Google Scholar 

  10. Grabinski C, Hussain S, Lafdi K, Braydich-Stolle L, Schlager J. Effect of particle dimension on biocompatibility of carbon nanomaterials. Carbon. 2007;45:2828–35.

    Article  CAS  Google Scholar 

  11. Rajzer I, Menaszek E, Bacakova L, Rom M, Blazewicz M. In vitro and in vivo studies on biocompatibility of carbon fibres. J Mater Sci Mater Med. 2010;21:2611–22.

    Article  CAS  Google Scholar 

  12. Kieswetter K, Schwartz Z, Dean DD, Doyan BD. The role of implant surface characteristics in the healing of bone. Crit Rev Oral Biol Med. 1996;7:329–45.

    Article  CAS  Google Scholar 

  13. Bordji K, Jouzeau JY, Mainard D, Payan E, Delagoutte JP, Netter P. Evaluation of the effect of three surface treatments on the biocompatibility of 316L stainless steel using human differentiated cells. Biomaterials. 1996;17:491–500.

    Article  CAS  Google Scholar 

  14. Puleo DA, Nanci A. Understanding and controlling the bone-implant interface. Biomaterials. 1999;20:2311–21.

    Article  CAS  Google Scholar 

  15. Jones FH. Teeth and bones: applications of surface science to dental materials and related biomaterials. Surf Sci Rep. 2001;42:75–205.

    Article  CAS  Google Scholar 

  16. Pesakova V, Kubies D, Hulejova H, Himmlova L. The influence of implant surface properties on cell adhesion and proliferation. J Mater Sci Mater Med. 2007;18:465–73.

    Article  CAS  Google Scholar 

  17. Stanford CM. Surface modification of biomedical and dental implants and the processes of inflammation, wound healing and bone formation. Int J Mol Sci. 2010;11:354–69.

    Article  CAS  Google Scholar 

  18. Bacakova L, Filova E, Parizek M, Ruml T, Svorcik V. Modulation of cell adhesion, proliferation and differentiation on materials designed for body implants. Biotechnol Adv. 2011;29:739–67.

    Article  CAS  Google Scholar 

  19. Anil S, Anand PS, Alghamdi H and Jansen JA. Dental implant surface enhancement and osseointegration, implant dentistry—a rapidly evolving practice, Prof. Ilser Turkyilmaz (Ed.), ISBN: 978-953-307-658-4, InTech 2011, Available from: http://www.intechopen.com/books/implant-dentistry-a-rapidly-evolving-practice/dental-implant-surface-enhancement-and-osseointegration.

  20. Bacaková L, Stary V, Kofronova O, Lisa V. Polishing and coating carbon fiber-reinforced carbon composites with a carbon-titanium layer enhances adhesion and growth of osteoblast-like MG63 cells and vascular smooth muscle cells in vitro. J Biomed Mat Res. 2001;54:567–78.

    Article  Google Scholar 

  21. Litzler PY, Benard L, Barbier-Frebourg N, Vilain S, Jouenne T, Beucher E, Bunel C, Lemeland JF, Bessou JP. Biofilm on pyrolytic carbon heart valves: Influence of surface free energy, roughness and bacterial species. J Thorac Cardiov Surg. 2007;134:1025–32.

    Article  Google Scholar 

  22. Ning C, Qiang-xiu W, Jian-wen D, Guang-zheng H, Mu-sen L. Characterization and biological behavior of carbon fiber/carbon composite scaffold with a porous surface for bone tissue reconstruction. New Carbon Mater. 2010;25:232–6.

    Article  Google Scholar 

  23. Lewandowska-Szumiel M, Komender J, Chlopek J. Interaction between carbon composites and bone after itrabone implantation. J Biomed Mater Res. 1999;48:289–96.

    Article  CAS  Google Scholar 

  24. Szabo G, Barabas J and Nemeth Z. Long-term comparison of CarBulat™ (pure carbon) and titanium mandibular reconstruction plates. In: Raspal G and Lagunas J G, editors. XVIII Congress of the European Association for Cranio-Maxillo Facial Surgery 2006 Barcelona, Medimond International Proceedings.

  25. Offele D, Harbeck M, Dobberstein RC, von Wurmb-Schwark N, Ritz-Timme S. Soft Tissue removal by maceration and feeding of Dermestes sp.: impact on morphological and biomolecular analyses of dental tissues in forensic medicine. Int J Legal Med. 2007;121:341–8.

    Article  Google Scholar 

  26. Kanaya K, Okayama S. Penetration and energy-loss theory of electrons in solid targets. J Phys D Appl Phys. 1972;5:43–58.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors would like to thank the help and work of V. K. Josepovits, M. Tóth, K. N. László at the Budapest University of Technology and Economics, E. Felszeghy at the Semmelweis University (Budapest) and Éva Sebők at the University of Copenhagen (Denmark). The authors are especially grateful to Mr. M. Gottesman the director of Ametist Goldy Management LLC (USA) for supplying the implants. This work was supported by the NHDP TÁMOP-4.2.1/B-09/1/KMR-2010-0002 programme.

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Authors and Affiliations

  1. Department of Atomic Physics, Budapest University of Technology and Economics, Budafoki út 8, Budapest, 1111, Hungary

    Béla Sebők, Gábor Kiss, Gábor Dobos & Ferenc Réti

  2. Department of Materials Science and Engineering, Budapest University of Technology and Economics, Budapest, Hungary

    Péter J. Szabó

  3. Department of Electronics Technology, Budapest University of Technology and Economics, Budapest, Hungary

    Dániel Rigler & Milán L. Molnár

  4. Men for Care Ltd., Százhalombatta, Hungary

    Hajnal Szőcs

  5. Department of Oro-Maxillofacial Surgery and Stomatology, Faculty of Dentistry, Semmelweis University, Budapest, Hungary

    Árpád F. Joób, Sándor Bogdán & György Szabó

Authors
  1. Béla Sebők
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  2. Gábor Kiss
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  3. Péter J. Szabó
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  4. Dániel Rigler
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  5. Milán L. Molnár
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  6. Gábor Dobos
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  7. Ferenc Réti
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  8. Hajnal Szőcs
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  9. Árpád F. Joób
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  10. Sándor Bogdán
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  11. György Szabó
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Correspondence to Béla Sebők.

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Sebők, B., Kiss, G., Szabó, P.J. et al. SEM and EDS investigation of a pyrolytic carbon covered C/C composite maxillofacial implant retrieved from the human body after 8 years. J Mater Sci: Mater Med 24, 821–828 (2013). https://doi.org/10.1007/s10856-012-4840-y

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  • DOI: https://doi.org/10.1007/s10856-012-4840-y

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