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Galactose substituted zinc phthalocyanines as near infrared fluorescence probes for liver cancer imaging

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Abstract

Galactose substituted with zinc phthalocyanines were synthesized and characterized as near infrared fluorescent probes. The probes have good water-solubility and high emission ability in the near infrared region. With nudemice bearing liver cancer as models, in vivo fluorescence imaging effects and organ distributions of probes show that zinc phthalocyanines with three or four galactose units have good cell biocompatibility in vitro and targeting effects for liver cancer imaging in vivo. These results show the potential of these near infrared optical probes in the diagnosis of cancer in future.

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Acknowledgments

This work was supported by the Ph. D. Programs Foundation of Ministry of Education of China (No.20101106120052), the National Nature Science Foundation of China (No.31200732) and the National Basic Research Program of China (No.2006CB705703).

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Authors and Affiliations

  1. Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, People’s Republic of China

    Feng Lv, Yanzhou Li, Bo Cao & Tianjun Liu

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  1. Feng Lv
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  2. Yanzhou Li
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  4. Tianjun Liu
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Correspondence to Tianjun Liu.

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Lv, F., Li, Y., Cao, B. et al. Galactose substituted zinc phthalocyanines as near infrared fluorescence probes for liver cancer imaging. J Mater Sci: Mater Med 24, 811–819 (2013). https://doi.org/10.1007/s10856-012-4820-2

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  • DOI: https://doi.org/10.1007/s10856-012-4820-2

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