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Properties of xyloglucan hydrogel as the biomedical sustained-release carriers

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Abstract

This study introduces an easy method of preparing xyloglucan hydrogel from xyloglucan, which is purified from tamarind seed gum. Xyloglucan hydrogel was prepared in 2 wt% solution by treating with β-galactosidase. Physical and chemical properties (molecular mass, size and viscosity) of xyloglucan hydrogel and xyloglucan solution were tested for a comparison. Experiments of drug release in vitro and in vivo were operated to investigate the potentialities of xyloglucan hydrogel as the biomedical sustained-release carriers for drug delivery system.

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Acknowledgments

This work was supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars (State Education Ministry, 2010–1174), self-determined research funds of CCNU from the colleges’ basic research and operation of MOE (CCNU11A02013) and the project of Hubei Key Laboratory of Genetic Regulation and Integrative Biology (201002).

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Correspondence to Yu Cao.

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Didi Chen and Pei Guo contributed equally to this work.

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Chen, D., Guo, P., Chen, S. et al. Properties of xyloglucan hydrogel as the biomedical sustained-release carriers. J Mater Sci: Mater Med 23, 955–962 (2012). https://doi.org/10.1007/s10856-012-4564-z

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  • DOI: https://doi.org/10.1007/s10856-012-4564-z

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