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Mechanical properties and in vivo performance of a novel sliding-lock bioabsorbable poly-p-dioxanone stent

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Abstract

A bioabsorbable poly-p-dioxanone (PPDO) stent with a novel sliding-lock structure was fabricated to treat stenotic peripheral vessels. The sliding-lock PPDO stents have greater radial strength (107 kPa) than PPDO stents with conventional net-tube structure (32 kPa). The sliding-lock PPDO stents were implanted into the iliac arteries of pigs, and implantation success rate was 90% indicating the feasibility of this design. Additionally, we found that sliding-lock PPDO stents kept vessels patent, although by 3 and 6 months post implantation, luminal diameter decreased slightly due to intimal hyperplasia. At 1 month post implantation, the stents were sparsely covered with endothelial cells, and by 6 months, the stents were mostly absorbed and inflammatory reaction gradually decreased as the stents were absorbed. This study shows favorable mechanical strength, degradability and efficacy for the sliding-lock PPDO stents, and supports further research and development of this unique design of polymer stents for applications in vascular devices.

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Acknowledgments

We thank Ruidong Zhang, Zuming Jiang, Xiaoqing Yu, and Yiwei Chen, from the Heart Center, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, China, for their excellent technical assistance. This work was supported by grants from the National Natural Science Foundation of China (No. 30772349), Science and Technology Commission of Shanghai Municipality, China (No. 07XD14015), and Shanghai Shenkang Hospital Development Center, China (No. SHDC12007107).

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Authors and Affiliations

  1. Children’s Heart Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200092, China

    Qimao Feng, Kun Sun, Sun Chen & Lijiao Zhao

  2. The State Key Laboratory of Metal Matrix Composites, Shanghai Jiaotong University, Shanghai, 200240, China

    Wenbo Jiang & Kang Sun

  3. Heart Center, Shanghai Children’s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, 200127, China

    Ke Dai & Ning Ma

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  1. Qimao Feng
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Correspondence to Kun Sun.

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Feng, Q., Jiang, W., Sun, K. et al. Mechanical properties and in vivo performance of a novel sliding-lock bioabsorbable poly-p-dioxanone stent. J Mater Sci: Mater Med 22, 2319 (2011). https://doi.org/10.1007/s10856-011-4407-3

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