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Hemocompatibility investigation of the NiTi alloy implanted with tantalum

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Abstract

A composite TiO2/Ta2O5 nano-film has been formed on the NiTi shape memory alloy by Ta implantation. The wettability, protein adsorption, platelets adhesion and hemolysis tests are conducted to evaluate the hemocompatibility. The contact angle measurements showed that the surface of the NiTi alloy kept hydrophilic before and after Ta implantation, although the water contact angle increased with the increasing of implantation current. Both of the surface energy and the interfacial tension decreased after Ta implantation. The protein adsorption behavior was investigated by 125I isotope labeling. The fibrinogen adsorption was enhanced by a high surface roughness or a large interfacial tension, while the albumin adsorption was insensitive to the surface modification. Platelet adhesion and activation were weakened and the hemolysis rate was reduced at least 46% after Ta implantation due to the decreased surface energy and improved corrosion resistance ability, respectively.

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Acknowledgments

This work is supported by National Natural Science Foundation of China (NSFC), No. 50971007 and the Innovation Foundation of BUAA for PhD Graduates. Yan Li acknowledges the funding by the Program for New Century Excellent Talents in University (NCET-09-0024).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Beihang University, #37, Xueyuan Road, Beijing, 100191, People’s Republic of China

    Tingting Zhao, Yan Li & Yuzhi Gao

  2. Key Laboratory of Aerospace Materials and Performance (Ministry of Education), Beihang University, Beijing, 100191, People’s Republic of China

    Tingting Zhao & Yan Li

  3. School of Chemistry and Environment, Beihang University, Beijing, 100191, People’s Republic of China

    Yan Xiang

  4. School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, 430070, China

    Hong Chen

  5. Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Beijing Normal University, Beijing, 100875, China

    Tao Zhang

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  1. Tingting Zhao
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  2. Yan Li
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Correspondence to Yan Li.

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Zhao, T., Li, Y., Gao, Y. et al. Hemocompatibility investigation of the NiTi alloy implanted with tantalum. J Mater Sci: Mater Med 22, 2311 (2011). https://doi.org/10.1007/s10856-011-4406-4

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