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Osteopenic bone cell response to strontium-substituted hydroxyapatite

Journal of Materials Science: Materials in Medicine volume 22, pages 2079–2088 (2011)Cite this article

Abstract

Ionic substitution is a powerful tool to improve the biological performance of calcium phosphate based materials. In this work, we investigated the response of primary cultures of rat osteoblasts derived from osteopenic (O-OB) bone to strontium substituted hydroxyapatite (SrHA), and to hydroxyapatite (HA) as reference material, compared to normal (N-OB) bone cells. Strontium (Sr) and calcium (Ca) cumulative releases in physiological solution are in agreement with the greater solubility of SrHA than HA, whereas the differences between the two materials are levelled off in DMEM, which significantly reduced ion release. O-OB cells grown on SrHA exhibited higher proliferation and increased values of the differentiation parameters. In particular, Sr substitution increased the levels of proliferation, alkaline phosphatase, and collagen type I, and down-regulated the production of interleukin-6 of O-OB cells, demonstrating a promising future of SrHA in the treatment of bone lesions and defects in the presence of osteoporotic bone.

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Acknowledgments

This research was carried out with the financial support of MIUR.

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Affiliations

  1. Department of Chemistry “G. Ciamician”, University of Bologna, 40126, Bologna, Italy

    E. Boanini & A. Bigi

  2. Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy

    P. Torricelli & M. Fini

Authors
  1. E. Boanini
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  2. P. Torricelli
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  3. M. Fini
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  4. A. Bigi
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Correspondence to A. Bigi.

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Boanini, E., Torricelli, P., Fini, M. et al. Osteopenic bone cell response to strontium-substituted hydroxyapatite. J Mater Sci: Mater Med 22, 2079–2088 (2011). https://doi.org/10.1007/s10856-011-4379-3

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  • DOI: https://doi.org/10.1007/s10856-011-4379-3

Keywords

  • Physiological Solution
  • Osteoporotic Bone
  • Cumulative Release
  • Osteopenic Bone
  • Bone Tissue Repair