Abstract
The aim of the study was to explore the feasibility of the Ca–P coating titanium alloy plate to be used as the vancomycin drug-delivery system by biomimetic coating technology. Through the X-ray diffraction study, the main components of the coatings were identified as octocalcium phosphate. The in vitro vancomycin release, bacteriostasis activity to Staphylococcus aureus (S. aureus), the scanning electron microscope (SEM) image and osteoblast adhesion and proliferation test of vancomycin-loaded Ca–P coating plate were evaluated. The bacteriostatic activity of the vancomycin-loaded Ca–P coating plate showed a continuous drug release and had an inhibitory effect on the growth of the S. aureus. In vitro osteoblast culture results showed that the Ca–P coating plate loaded with or without the vancomycin both obviously promoted the osteoblast attachment. It was suggested that the vancomycin-loaded Ca–P coating may be compounded in the surface of the internal fixators to reduce the incidence of the implant-associated infection.
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Acknowledgments
This study was supported by Grants from the National Natural Science Foundation of China (Nos. 30700177, 81071459), Tackle Key Problems in Technology Foundation of Chongqing (No. CSTC, 2009AC5022) and Chinese Postdoctoral Science Foundation (Nos. 20090460108, 201003775). We thank Chongqing University Bioengineering Institute for providing technical support in the vancomycin-loaded Ca–P titanium alloy plate.
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Jun Fei and Guo-dong Liu shared the same duties in this study.
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Fei, J., Liu, Gd., Pan, Cj. et al. Preparation, release profiles and antibacterial properties of vancomycin-loaded Ca–P coating titanium alloy plate. J Mater Sci: Mater Med 22, 989–995 (2011). https://doi.org/10.1007/s10856-011-4277-8
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DOI: https://doi.org/10.1007/s10856-011-4277-8