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Carbon nanotubes linked with pitavastatin: synthesis and characterisation

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Abstract

The paper presents a study on functionalisation of multi-walled carbon nanotubes in the area of lattice defects and an attempt to bind the nanotubes with pitavastatin. Carbon nanotubes were synthesised by alcohol-chemical vapour deposition in the presence of the catalyst Fe–Co/MgO. The nanotubes were purified and the product was subjected to chemical functionalisation. Functional groups were introduced in the reaction of the purified nanotubes with thionyl chloride to obtain acidic chlorides linked to pitavastatin. The properties and structure of the nanotubes were analysed by FT-IR and Raman spectroscopies, transmission electron microscopy and liquid chromatography coupled with mass spectrometry. Photochemical stability of pitavastatin linked with carbon nanotubes has been found to be increased.

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Authors and Affiliations

  1. Institute of Chemical and Environment Engineering, West Pomerania University of Technology, Szczecin, Poland

    E. Borowiak-Palen

  2. Department of Inorganic and Analytical Chemistry, University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland

    P. Skupin, M. Kruszynska, L. Sobotta & J. Mielcarek

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  1. E. Borowiak-Palen
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  2. P. Skupin
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  3. M. Kruszynska
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  4. L. Sobotta
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  5. J. Mielcarek
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Correspondence to J. Mielcarek.

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Borowiak-Palen, E., Skupin, P., Kruszynska, M. et al. Carbon nanotubes linked with pitavastatin: synthesis and characterisation. J Mater Sci: Mater Med 22, 845–851 (2011). https://doi.org/10.1007/s10856-011-4260-4

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  • DOI: https://doi.org/10.1007/s10856-011-4260-4

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