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Formation and properties of magnesium–ammonium–phosphate hexahydrate biocements in the Ca–Mg–PO4 system

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Abstract

Calcium substituted trimagnesium phosphate with the general formula CaxMg(3−x)(PO4)2 (0 < x < 1.5) was synthesized by calcination of powder mixtures with the appropriate stoichiometry and reacted with 3.5 M diammonium hydrogenphosphate solution to form a cementitious matrix of magnesium ammonium phosphate hexahydrate (struvite). The degree of ionic substitution was shown to influence physical cement properties; clinically suitable cement formulations with setting times in the range 5–15 min and compressive strengths of >50 MPa were obtained for x ≤ 0.75 together with a grinding time ≥1 h and a powder to liquid ratio ≥2.5 g/ml. The cement cytocompatibility was investigated by culturing human osteoblast cell line MG63 on cement surfaces demonstrating pronounced cell growth during 13 days cultivation.

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Acknowledgment

The authors would like to acknowledge financial support from the Deutsche Forschungsgemeinschaft (DFG Gb1/11-1 and DFG Mu1803/7-1).

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Authors and Affiliations

  1. Department for Functional Materials in Medicine and Dentistry, University of Würzburg, Pleicherwall 2, D-97070, Würzburg, Germany

    Elke Vorndran, Andrea Ewald, Andreas Kufner & Uwe Gbureck

  2. Institute of Materials Science and Technology (IMT), Friedrich-Schiller-University of Jena, Löbdergraben 32, 07743, Jena, Germany

    Frank A. Müller & Katharina Zorn

Authors
  1. Elke Vorndran
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  2. Andrea Ewald
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  3. Frank A. Müller
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  4. Katharina Zorn
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  5. Andreas Kufner
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  6. Uwe Gbureck
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Correspondence to Uwe Gbureck.

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Vorndran, E., Ewald, A., Müller, F.A. et al. Formation and properties of magnesium–ammonium–phosphate hexahydrate biocements in the Ca–Mg–PO4 system. J Mater Sci: Mater Med 22, 429–436 (2011). https://doi.org/10.1007/s10856-010-4220-4

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  • DOI: https://doi.org/10.1007/s10856-010-4220-4

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