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Hydrogels based on chitosan–xanthan for controlled release of theophylline

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Abstract

The aim of this paper is theophylline (THP) inclusion into xanthan–chitosan polyionic complex (Xa–CS) and the study of its in vitro and in vivo kinetic release. Xa–CS hydrogel was obtained by ionic complexation between two oppositely charged polysaccharides. THP was loaded into the Xa–CS matrix by diffusion of the drug solution. The obtained samples were characterized by FTIR spectroscopy, SEM microscopy and study of the swelling behavior. THP in vitro release experiments were carried out in conditions mimicking the gastrointestinal environment. The chosen drug dose for in vivo study was 15 mg THP/Kg body weight of THP powder or an equivalent dose in complex form. THP serum concentrations were determined by an HPLC assay. The THP peak serum concentration (C max) was 7.18 μg/ml for free THP and AUC0–48 was 25.76 μg h/ml, while in the case of Xa–CS–THP, C max was of 5.72 μg/ml and AUC0–48 = 45.72 μg h/ml. The in vivo study regarding the behaviour of the obtained formulation, showed an increase bioavailability of THP compared to the raw drug, suggesting the possible application of the complex Xa–CS as an oral controlled drug delivery system in the management of chronic pulmonary obstructive disease.

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Acknowledgements

The work was financially supported by Ministry of Education and Science Romania, project PNCD II 41-017/2007.

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Authors and Affiliations

  1. Faculty of Chemical Engineering and Environmental Protection, Technical University Gh. Asachi, D. Mangeron Boulevard, 700050, Iasi, Romania

    Niculina Popa, Ovidiu Novac & Marcel Ionel Popa

  2. University of Medicine and Pharmacy Gr. T. Popa, Universitatii Street, Nr. 16, 700115, Iasi, Romania

    Lenuta Profire & Catalina Elena Lupusoru

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  1. Niculina Popa
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  2. Ovidiu Novac
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  3. Lenuta Profire
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  4. Catalina Elena Lupusoru
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  5. Marcel Ionel Popa
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Correspondence to Marcel Ionel Popa.

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Popa, N., Novac, O., Profire, L. et al. Hydrogels based on chitosan–xanthan for controlled release of theophylline. J Mater Sci: Mater Med 21, 1241–1248 (2010). https://doi.org/10.1007/s10856-009-3937-4

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  • DOI: https://doi.org/10.1007/s10856-009-3937-4

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