Effect of strontium-containing hydroxyapatite bone cement on bone remodeling following hip replacement


DOI: 10.1007/s10856-009-3866-2

Cite this article as:
Ni, G.X., Lin, J.H., Chiu, P.K.Y. et al. J Mater Sci: Mater Med (2010) 21: 377. doi:10.1007/s10856-009-3866-2


It is uncertain whether the use of bioactive bone cement has any beneficial effect on local bone adaptation following hip replacement. In this study, twelve goats underwent cemented hip hemiarthroplasty unilaterally, with either PMMA bone cement or strontium-containing hydroxyapatite (Sr-HA) bioactive bone cement. Nine months later, the femoral cortical bones at different levels were analyzed by microhardness testing and micro-CT scanning. Extensive bone remodeling was found at proximal and mid-levels in both PMMA and Sr-HA groups. However, with regard to the differences of bone mineral density, cortical bone area and bone hardness between implanted and non-implanted femur, less decreases were found in Sr-HA group than PMMA group at proximal and mid-levels, and significant differences were shown for bone area and hardness at proximal level. The results suggested that the use of Sr-HA cement might alleviate femoral bone remodeling after hip replacement.

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© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  1. 1.Department of Rehabilitation MedicineFujian Medical UniversityFuzhouChina
  2. 2.Department of Orthopaedic Surgery, No. 1 Affiliated HospitalFujian Medical UniversityFuzhouChina
  3. 3.Department of Orthopaedics and TraumatologyThe University of Hong KongHong KongHong Kong

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