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Real time monitoring of the polymerisation of PMMA bone cement using Raman spectroscopy

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Abstract

In this investigation Raman spectroscopy was shown to be a method that could be used to monitor the polymerisation of PMMA bone cement. Presently there is no objective method that orthopaedic surgeons can use to quantify the curing process of cement during surgery. Raman spectroscopy is a non-invasive, non-destructive technique that could offer such an option. Two commercially available bone cements (Palacos® R and SmartSet® HV) and different storage conditions (4 and 22°C) were used to validate the technique. Raman spectroscopy was found to be repeatable across all conditions with the completion of the polymerisation process particularly easy to establish. All tests were benchmarked against current temperature monitoring methods outlined in ISO and ASTM standards. There was found to be close agreement with the standard methods and the Raman spectroscopy used in this study.

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References

  1. Kuehn KD, Ege W, Gopp U. Acrylic bone cements: composition and properties. Orthop Clin N Am. 2005;36:17–28.

    Article  Google Scholar 

  2. Dunne NJ, Xu Y, Makem J, Orr J. Ultrasonic characterisation of the mechanical properties and polymerisation reaction of acrylic based bone cements. Proc IMechE H. 2006;221:251–61.

    Article  Google Scholar 

  3. Dunne NJ, Orr JF. Curing characteristics of acrylic bone cement. J Mater Sci: Mater Med. 2002;13(1):17–22.

    Article  CAS  Google Scholar 

  4. ISO 5833. (International Organisation for Standards, Geneva, 2002).

  5. Meyer PR, Lautenschlager EP, Moore BK. On the setting properties of acrylic bone cement. J Bone Joint Surg. 1973;55(1):149–56.

    PubMed  Google Scholar 

  6. He S, Scott C, De Luise M, Edwards B, Higham P. Effect of choice of surgical gloves on dough time measurements of acrylic bone cement. Biomaterials. 2003;24(2):235–7.

    Article  CAS  PubMed  Google Scholar 

  7. Viano AM, Auwarter JA, Rho JY, Hoffmeister BK. Ultrasonic characterization of the curing process of hydroxyapatite-modified bone cement. J Biomed Mater Res. 2001;56(4):593–9.

    Article  CAS  PubMed  Google Scholar 

  8. Rehman I, Harper EJ, Bonfield W. In-situ analysis of the degree of polymerisation of bone cement by using FT-Raman spectroscopy. Biomaterials. 1996;17(16):1615–9.

    Article  CAS  PubMed  Google Scholar 

  9. Smith E, Dent G. Modern Raman spectroscopy—a practical approach. Great Britain: Wiley; 2005.

    Google Scholar 

  10. Barnes SE, Brown EC, Corrigan N, Coates PD, Harkin-Jones E, Edwards HGM. Raman spectroscopic studies of the cure of dicyclopentadiene (DCPD). Spectrochim Acta A. 2005;61:2946–52.

    Article  CAS  Google Scholar 

  11. Gulari E, McKeigue K, Ng KYS. Raman and FTIR spectroscopy of polymerization: bulk polymerization of methyl methacrylate and styrene. Macromolecules. 1984;17:1822–5.

    Article  CAS  ADS  Google Scholar 

  12. Kuehn KD. Bone cements—up to date comparison of physical and chemical properties of commercial materials. Berlin: Springer; 2000.

    Google Scholar 

  13. Orr JF, Dunne NJ, Quinn JC. Shrinkage stresses in bone cement. Biomaterials. 2003;24(17):2933–40.

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. School of Mechanical and Aerospace Engineering, Queens University Belfast, Stranmillis Road, Belfast, BT9 5AH, UK

    Christopher P. Hagan, John F. Orr & Nicholas J. Dunne

  2. School of Medicine, Dentistry and Biomedical Sciences, Queens University Belfast, Grosvenor Road, Belfast, BT12 6BP, UK

    Christina A. Mitchell

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  1. Christopher P. Hagan
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  2. John F. Orr
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  3. Christina A. Mitchell
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  4. Nicholas J. Dunne
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Correspondence to Nicholas J. Dunne.

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Hagan, C.P., Orr, J.F., Mitchell, C.A. et al. Real time monitoring of the polymerisation of PMMA bone cement using Raman spectroscopy. J Mater Sci: Mater Med 20, 2427–2431 (2009). https://doi.org/10.1007/s10856-009-3822-1

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  • DOI: https://doi.org/10.1007/s10856-009-3822-1

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