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Feasibility, tailoring and properties of polyurethane/bioactive glass composite scaffolds for tissue engineering

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Abstract

This research work aims to propose highly porous polymer/bioactive glass composites as potential scaffolds for hard-tissue and soft-tissue engineering. The scaffolds were prepared by impregnating an open-cells polyurethane sponge with melt-derived particles of a bioactive glass belonging to the SiO2–P2O5–CaO–MgO–Na2O–K2O system (CEL2). Both the starting materials and the composite scaffolds were investigated from a morphological and structural viewpoint by X-ray diffraction analysis and scanning electron microscopy. Tensile mechanical tests, carried out according to international ISO and ASTM standards, were performed by using properly tailored specimens. In vitro tests by soaking the scaffolds in simulated body fluid (SBF) were also carried out to assess the bioactivity of the porous composites. It was found that the composite scaffolds were highly bioactive as after 7 days of soaking in SBF a HA layer grew on their surface. The obtained polyurethane/CEL2 composite scaffolds are promising candidates for tissue engineering applications.

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Acknowledgements

The authors gratefully acknowledge the financial support of Regione Piemonte (Ricerca Sanitaria Finalizzata) supplied for this work.

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Authors and Affiliations

  1. Materials Science and Chemical Engineering Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Torino, Italy

    Francesco Baino, Enrica Verné & Chiara Vitale-Brovarone

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  1. Francesco Baino
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  2. Enrica Verné
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  3. Chiara Vitale-Brovarone
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Correspondence to Francesco Baino.

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Baino, F., Verné, E. & Vitale-Brovarone, C. Feasibility, tailoring and properties of polyurethane/bioactive glass composite scaffolds for tissue engineering. J Mater Sci: Mater Med 20, 2189–2195 (2009). https://doi.org/10.1007/s10856-009-3787-0

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  • DOI: https://doi.org/10.1007/s10856-009-3787-0

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