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Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by osteosarcoma cells

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Abstract

Nanoparticles have been extensively used for a variety of biomedical applications and there is a growing need for highly specific and efficient delivery of the nanoparticles into target cells and subcellular location. We attempted to accomplish this goal by modifying gold particles with peptide motif’s that are known to deliver a ‘cargo’ into chosen cellular location specifically, we intended to deliver nanogold particles into cells through chemical cross-linking with different peptides known to carry protein into cells. Our results suggest that specific sequence of such ‘carrier peptides’ can efficiently deliver gold nanoparticles into cells when chemically cross-linked with the metal particles.

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Acknowledgment

This work has been supported by NIH Grant #AR47974.

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Author notes

  1. Deendayal Mandal

    Present address: Department of Biomedical Sciences, University of Rhode Island, 41 Lower College Road, Kingston, 02881-0809, RI, USA

Authors and Affiliations

  1. Department of Orthopedics, Mayo Clinic and Foundation, Rochester, MN, 55905, USA

    Deendayal Mandal, Avudaippan Maran, Michael J. Yaszemski, Mark E. Bolander & Gobinda Sarkar

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  1. Deendayal Mandal
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  2. Avudaippan Maran
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  3. Michael J. Yaszemski
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  4. Mark E. Bolander
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  5. Gobinda Sarkar
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Correspondence to Deendayal Mandal.

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Mandal, D., Maran, A., Yaszemski, M.J. et al. Cellular uptake of gold nanoparticles directly cross-linked with carrier peptides by osteosarcoma cells. J Mater Sci: Mater Med 20, 347–350 (2009). https://doi.org/10.1007/s10856-008-3588-x

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  • DOI: https://doi.org/10.1007/s10856-008-3588-x

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