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Studies on in vitro biostability and blood compatibility of polyurethane potting compound based on aromatic polymeric MDI for extracorporeal devices

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Abstract

Polyurethane potting compound based on aromatic isocyanurate of polymeric MDI, poly propylene glycol (PPG400) and trimethylol propane (TMP) has significant favourable properties, good pot life and setting characteristics. The cured potting compound of this formulation has appreciable thermal stability and mechanical properties. In vitro biostability of cured potting compound has been found to be excellent without any significant degradation in simulated physiological media and chemical environment. Studies on blood–material interaction and cytotoxicity reveal in vitro blood compatibility and compatibility with cells of this potting compound.

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Acknowledgements

The authors are grateful to the Prof. K. Mohandas, Director, Sree Chitra Tirunal Institute for Medical sciences and Technology and Dr. G. S. Bhuvaneshwar, Head, Biomedical Technology Wing, SCTIMST, Trivandrum for providing the support and facilities.

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Authors and Affiliations

  1. Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, 695012, India

    V. K. Hridya & M. Jayabalan

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  1. V. K. Hridya
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  2. M. Jayabalan
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Correspondence to M. Jayabalan.

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Hridya, V.K., Jayabalan, M. Studies on in vitro biostability and blood compatibility of polyurethane potting compound based on aromatic polymeric MDI for extracorporeal devices. J Mater Sci: Mater Med 20 (Suppl 1), 195–202 (2009). https://doi.org/10.1007/s10856-008-3515-1

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  • DOI: https://doi.org/10.1007/s10856-008-3515-1

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