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Injectable iron-modified apatitic bone cement intended for kyphoplasty: cytocompatibility study

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Abstract

In this study, the cytocompatibility of human ephitelial (HEp-2) cells cultured on new injectable iron-modified calcium phosphate cements (IM-CPCs) has been investigated in terms of cell adhesion, cell proliferation, and morphology. Quantitative MTT-assay and scanning electron microscopy (SEM) showed that cell adhesion and viability were not affected with culturing time by iron concentration in a dose-dependent manner. SEM-cell morphology showed that HEp-2 cells, seeded on IM-CPCs, were able to adhere, spread, and attain normal morphology. These results showed that the new injectable IM-CPCs have cytocompatible features of interest to the intended kyphophasty application, for the treatment of osteoporotic vertebral compression fractures.

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Acknowledgments

The authors thank funding through projects SGR200500732 (Generalitat de Catalunya) and MAT200502778 (Ministerio de Educación y Ciencia of Spain).

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Authors and Affiliations

  1. Division of Biomaterials & Bioengineering, Interdepartment Research Group for the Applied Scientific Collaboration (IRGASC), Technical University of Catalonia (UPC), Avda. Diagonal 647, 08028, Barcelona, Spain

    M. D. Vlad, M. Barracó, J. López, R. Torres & E. Fernández

  2. Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Gr. T. Popa”, Str. Kogalniceanu 9-13, 700454, Iasi, Romania

    M. D. Vlad & I. Poeata

  3. Department of Agri-Food Engineering and Biotechnology (DEAB), ESAB, UPC, Avda. Canal Olimpic 15, 08860, Castelldefels, Spain

    L. J. del Valle

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  1. M. D. Vlad
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Correspondence to E. Fernández.

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Vlad, M.D., del Valle, L.J., Poeata, I. et al. Injectable iron-modified apatitic bone cement intended for kyphoplasty: cytocompatibility study. J Mater Sci: Mater Med 19, 3575–3583 (2008). https://doi.org/10.1007/s10856-008-3513-3

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  • DOI: https://doi.org/10.1007/s10856-008-3513-3

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