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Synthesis and characterization of biodegradable poly (ethylene glycol) and poly (caprolactone diol) end capped poly (propylene fumarate) cross linked amphiphilic hydrogel as tissue engineering scaffold material

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Abstract

Biodegradable poly (caprolactone diol-co-propylene fumarate-co-ethylene glycol) amphiphilic polymer with poly (ethylene glycol) and poly (caprolactone diol) chain ends (PCL–PPF–PEG) was prepared. PCL–PPF–PEG undergoes fast setting with acrylamide (aqueous solution) by free radical polymerization and produces a crosslinked hydrogel. The cross linked and freeze-dried amphiphilic material has porous and interconnected network. It undergoes higher degree of swelling and water absorption to form hydrogel with hydrophilic and hydrophobic domains at the surface and appreciable tensile strength. The present hydrogel is compatible with L929 fibroblast cells. PCL–PPF–PEG/acrylamide hydrogel is a candidate scaffold material for tissue engineering applications.

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Acknowledgements

The authors thank Prof. K. Mohandas, Director, Sree Chitra Tirunal Institute for Medical sciences and Technology and Dr. G.S. Bhuvaneshwar, Head, Biomedical Technology Wing, SCTIMST, Trivandrum for providing the support and facilities. The authors also thank Dr. Renuka Nair for her guidance and help in tissue culture. The authors acknowledge the financial support of Department of Biotechnology, New Delhi (No. BT/PR6524/Med/14/831/2005).

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Authors and Affiliations

  1. Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, 695 012, India

    Lekshmi Krishna & Muthu Jayabalan

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  1. Lekshmi Krishna
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  2. Muthu Jayabalan
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Correspondence to Muthu Jayabalan.

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Krishna, L., Jayabalan, M. Synthesis and characterization of biodegradable poly (ethylene glycol) and poly (caprolactone diol) end capped poly (propylene fumarate) cross linked amphiphilic hydrogel as tissue engineering scaffold material. J Mater Sci: Mater Med 20 (Suppl 1), 115–122 (2009). https://doi.org/10.1007/s10856-008-3493-3

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  • DOI: https://doi.org/10.1007/s10856-008-3493-3

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