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Fabrication, chemical composition change and phase evolution of biomorphic hydroxyapatite

Journal of Materials Science: Materials in Medicine volume 19, Article number: 3373 (2008) Cite this article

Abstract

Biomorphous, highly porous hydroxyapatite (HA) ceramics have been prepared by a combination of a novel biotemplating process and a sol–gel method, using natural plants like cane and pine as biotemplates. A HA sol was first synthesized from triethylphosphate and calcium nitrate used as the phosphorus and calcium precursors, respectively, and infiltrated into the biotemplates, and subsequently they were sintered at elevated temperatures to obtain porous HA ceramics. The microstructural changes, phase and chemical composition evolutions during the biotemplate-to-HA conversion were investigated by scanning electron microscopy (SEM), X-ray powder diffraction (XRD), and Fourier-transform infrared (FT-IR) spectroscopy. The XRD and FT-IR analysis revealed that the dominant phase of the product was HA, which contained a small amount of mixed A/B-type carbonated HA, closely resembling that of human bone apatite. Moreover, the appearance of a small amount of secondary phase CaCO3 seemed unavoidable. The HA was not transformed to the other calcium phosphate phases up to 1400°C, but it contained a trace amount of CaO when sintered at above 1100°C. The possible transformation mechanism was proposed. The SEM observation and mechanical property test showed that as-produced HA ceramics retained the macro-/micro-porous structures of the biotemplates with high precision, and possessed acceptable mechanical strength, which is suggested to be potential scaffolds for bone tissue engineering.

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Acknowledgements

This work is financially supported by the National Natural Science Foundation of China (No. 50603020 and No. 50773062) and the Program for New Century Excellent Talents in University (NCET-07-0673).

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  1. State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an, 710049, China

    Junmin Qian, Yahong Kang, Wei Zhang & Zhe Li

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Qian, J., Kang, Y., Zhang, W. et al. Fabrication, chemical composition change and phase evolution of biomorphic hydroxyapatite. J Mater Sci: Mater Med 19, 3373 (2008). https://doi.org/10.1007/s10856-008-3475-5

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Keywords

  • Cane
  • CaCO3
  • Sinter Temperature
  • Bioactive Glass
  • Bone Tissue Engineering