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Development of two alginate-based wound dressings

  • Chih-Tung Chiu
  • Jui-Sheng Lee
  • Chi-Shung Chu
  • Yi-Pin Chang
  • Yng-Jiin Wang
Article

Abstract

Two types of new alginate-based wound dressings, Type-AP and Type-AE, were fabricated by the EDC-activated crosslinking of alginate with Polyethyleneimine and Ethylenediamine, respectively. As compared with the commercial non-woven wound dressing, Kaltostat®, both Type-AP and Type-AE dressings had higher degradation temperature, lower calcium content, and a sponge-like macroporous structure. In addition, these two alginate-based dressings had higher mechanical stress (12.37 ± 1.72 and 6.87 ± 0.5 MPa for Type-AP and -AE, respectively) and higher water vapor transmission rates (both about 3,500 g/m2/day) than KaltostatR (0.87 ± 0.12 MPa and 2,538 g/m2/day). Fibroblasts proliferated faster on these two newly developed wound dressings at a higher rate as compared with that on Kalostat® dressing. The results of animal study showed that the wounds treated with either Type-AP or Type-AE dressings healed faster than Kaltostat® with less encapsulation of residuals by fibrous tissue and more neo-capillary formation. These two newly developed Type-AP and Type-AE porous wound dressings thus have great potential for clinical applications.

Keywords

Alginate Wound Dressing Water Vapor Transmission Rate Sodium Calcium Alginate Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Chih-Tung Chiu
    • 1
  • Jui-Sheng Lee
    • 2
  • Chi-Shung Chu
    • 2
  • Yi-Pin Chang
    • 1
  • Yng-Jiin Wang
    • 1
  1. 1.Institute of Biomedical EngineeringNational Yang Ming UniversityTaipeiTaiwan, ROC
  2. 2.Department of Raw Materials and Yarn Formation SectionTaiwan Textile Research InstituteTaipeiTaiwan, ROC

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