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Zirconium oxide regulates RNA interfering of osteoblast-like cells

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Abstract

Zirconium oxide (ZO) has outstanding mechanical properties, high biocompatibility and high resistance to scratching. Since dental implants are made with ZO and the genetic effects of ZO on osteoblasts are incompletely understood, we used microRNA microarray techniques to investigate the translation process in osteoblasts exposed to ZO. By using miRNA microarrays containing 329 probes designed from Human miRNA sequences, we identified in osteoblast-like cells line (MG-63) cultured on ZO disks several miRNA whose expression was significantly modified. The most notable regulated genes acting on osteoblasts are: NOG, SHOX, IGF1, BMP1 and FGFR1. The data reported below represent the first study on translation regulation in osteoblasts exposed to zirconium and one in which the effect of ZO on bone formation has been detected.

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Acknowledgments

This work was supported by grants from the University of Ferrara, Italy (F.C.), PRIN 2005 prot. 2005067555-002 (F.C.), Fondazione CARIFE (F.C.), and Fondazione CARISBO (F.P.).

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Authors and Affiliations

  1. Institute of Histology, University of Bologna and Center of Molecular Genetics, CARISBO Foundation, Bologna, Italy

    Annalisa Palmieri, Furio Pezzetti, Marcella Martinelli, Luca Scapoli, Marzia Arlotti & Elena Masiero

  2. Department of DMCCC, Section of Maxillofacial Surgery, University of Ferrara, Ferrara, 44100, Italy

    Giorgio Brunelli, Ilaria Zollino & Francesco Carinci

  3. Dental Clinic, University of Foggia, Foggia, Italy

    Lorenzo Lo Muzio

Authors
  1. Annalisa Palmieri
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  2. Furio Pezzetti
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  3. Giorgio Brunelli
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  4. Ilaria Zollino
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  5. Lorenzo Lo Muzio
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  9. Elena Masiero
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  10. Francesco Carinci
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Correspondence to Francesco Carinci.

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Palmieri, A., Pezzetti, F., Brunelli, G. et al. Zirconium oxide regulates RNA interfering of osteoblast-like cells. J Mater Sci: Mater Med 19, 2471–2476 (2008). https://doi.org/10.1007/s10856-008-3386-5

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  • DOI: https://doi.org/10.1007/s10856-008-3386-5

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