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Novel method of preparing hydroxyapatite foams

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Abstract

Porous scaffolds are considered a key strategy in the concept of bone tissue engineering. Hydroxyapatite, which is a bioceramic has been used as a popular scaffold material due to its bioactive and osteoconductive properties. A combination of slurry-dipping and electrospraying has been used as a new foam fabrication method to produce porous and interconnected foam structures. The combined method has shown to overcome the shortcomings of the individual methods and it has produced open pores in the desired range of 100–350 μm. The porosity which was determined by calculation and microtomography was between 84% and 88%. Reduced cracks and thicker struts were observed in the microstructure, pointing to improved mechanical properties.

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Acknowledgements

Authors would like to thank Jenny Robinson and Dr. Serena Best (Department of Materials Science and Metallurgy, University of Cambridge) for the preparation of the original 18 wt.% nHA suspension, and Dr. Pete Laity (University of Cambridge) for assistance with microtomography imaging. EPSRC grants: GR/S 97880, GR/S 97873 and the Royal Society, UK (Brian Mercer Fund) are gratefully acknowledged for their support in funding the research.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK

    Anushini Muthutantri, Jie Huang & Mohan Edirisinghe

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  1. Anushini Muthutantri
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  2. Jie Huang
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  3. Mohan Edirisinghe
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Correspondence to Mohan Edirisinghe.

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Muthutantri, A., Huang, J. & Edirisinghe, M. Novel method of preparing hydroxyapatite foams. J Mater Sci: Mater Med 19, 1485–1490 (2008). https://doi.org/10.1007/s10856-008-3379-4

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  • DOI: https://doi.org/10.1007/s10856-008-3379-4

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