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Toward modulating the architecture of hydrogel scaffolds: curtains versus channels

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Abstract

The design, development and evaluation of biomaterials that can sustain life or restore a certain body function, is a very important and rapidly expanding field in materials science. A key issue in the development of biomaterials is the design of a material that mimics the natural environment of cells. In the present work, we have therefore developed hydrogel materials that contain both a protein (gelatin) and a glycosaminoglycan (chondroitin sulphate) component. To enable a permanent crosslinking, gelatin and chondroitin sulphate were first chemically modified using methacrylic anhydride. Hydrogels containing modified gelatin (gel-MOD) and/or chondroitin sulphate (CS-MOD) were cryogenically treated as optimised earlier for gel-MOD based hydrogels (Van Vlierberghe et al., Biomacromolecules 8:331–337, 2007). The cryogenic treatment leads to tubular pores for gel-MOD based systems. For CS-MOD based hydrogels and hydrogels containing both gel-MOD and CS-MOD, a curtain-like architecture (i.e. parallel plates) was observed, depending on the applied CS-MOD concentration. In our opinion, this is the first paper in which such well-defined scaffold architectures have been obtained without using rapid prototyping techniques.

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Acknowledgements

The authors would like to acknowledge the Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT) for the Ph.D. funding granted to S. Van Vlierberghe, the Alexander von Humboldt Foundation for the financial support under the form of a granted Research Fellowship and the Belgian Research Policy Inter University Attraction Poles (IUAP/PAI-V/03) for financial support.

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Authors and Affiliations

  1. Polymer Chemistry & Biomaterials Research Group, Ghent University, Krijgslaan 281 S4-bis, 9000, Ghent, Belgium

    S. Van Vlierberghe, P. Dubruel & E. Schacht

  2. Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, Louis Pasteurlaan 2, 9000, Ghent, Belgium

    E. Lippens & M. Cornelissen

  3. Department of Subatomic and Radiation Physics, Ghent University, Proeftuinstraat 86, 9000, Ghent, Belgium

    B. Masschaele & L. Van Hoorebeke

  4. Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101, Mainz, Germany

    R. Unger & C. J. Kirkpatrick

Authors
  1. S. Van Vlierberghe
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  2. P. Dubruel
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  3. E. Lippens
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  4. B. Masschaele
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  5. L. Van Hoorebeke
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  6. M. Cornelissen
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  7. R. Unger
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  8. C. J. Kirkpatrick
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  9. E. Schacht
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Corresponding author

Correspondence to E. Schacht.

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Van Vlierberghe, S., Dubruel, P., Lippens, E. et al. Toward modulating the architecture of hydrogel scaffolds: curtains versus channels. J Mater Sci: Mater Med 19, 1459–1466 (2008). https://doi.org/10.1007/s10856-008-3375-8

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  • DOI: https://doi.org/10.1007/s10856-008-3375-8

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