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Biomechanical studies on aliphatic physically crosslinked poly(urethane urea) for blood contact applications

Journal of Materials Science: Materials in Medicine volume 19, pages 2721–2733 (2008)Cite this article

Abstract

Hydrophobic and physically crosslinked (virtually crosslinked through hydrogen bonding) aliphatic poly(urethane urea)s were developed and characterized for its biomechanical properties. The aging under induced-stress (bend samples) condition reveals resistance of poly(urethane urea) to environmental stress corrosion cracking (ESC) in hydrolytic media, Ringer’s solution and phosphate buffered saline at 50°C. The strain-induced (20% tensile strain) and aged polymer in hydrolytic enzyme medium, papain and in buffer reveals increase of elastic modulus in papain enzyme and papain buffer. The increase of elastic modulus is attributed to unidirectional reorganisation of chains under continually strained conditions. The polymer exposed in boiling alcoholic potassium hydroxide solution (accelerated hydrolytic chemical degradation) reveals no degradation. A comparative evaluation of poly(ether urethane urea)s reveals inferior properties. Poly(ether urethane urea)s polymer undergo hydrolytic degradation in boiling alcoholic potassium hydroxide solution. The candidate poly(urethane urea) HFL 18-PUU is more promising elastomer for long-term biomechanically sensitive blood contact applications such as heart valve and blood pump diaphragm of left ventricular assist device.

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References

  1. V. Poirier, Trans ASIO. XXXVI, 787 (1990)

    Article  Google Scholar 

  2. K. Hayashi, H. Takano, T. Matsuda, M. Umezu, J. Biomed. Mater. Res. 19, 179 (1985)

    Article  CAS  Google Scholar 

  3. K.B. Stokes, M.W. Davis, Polym. Sci. Technol. 35, 147 (1987)

    CAS  Google Scholar 

  4. M. Szycher, V.C. Poirier, D.T. Demsey, J. Elastomer. Plast. 15, 81 (1983)

    Article  CAS  Google Scholar 

  5. A. Mazzu, C.P. Smith, J. Biomed. Mater. Res. 18, 967 (1983)

    Google Scholar 

  6. M. Jayabalan, K. Rathinam, Clin. Mater. 11, 179 (1992)

    Article  CAS  Google Scholar 

  7. M. Jayabalan, N. Shunmuga Kumar, Med. Prog. Though Tech. 20, 201 (1994)

    Google Scholar 

  8. W.J. Kolff, L.S. Yu, Ann. Thorac. Surg. 48, 5987 (1989)

    Article  Google Scholar 

  9. M.E. Leat, O.K. Gilding, J. Fisher, I.P. Middleton, S.A. Dixon, in Biomaterial-tissue interfaces, ed. by P.J. Doherty, R.L. Williams, D.F. Williams, A.J.C. Lee (Elsevier, Amsterdam, 1992), p. 133

  10. V. Thomas, T.V. Kumari, M. Jayabalan, Biomacromolecules 2, 588 (2001)

    Article  CAS  Google Scholar 

  11. V. Thomas, M. Jayabalan, J. Biomed. Mater. Res. 56, 144 (2001)

    Article  CAS  Google Scholar 

  12. V. Thomas, M. Jayabalan, Biomaterials 23, 273 (2001)

    Article  Google Scholar 

  13. L. Ning, W. De-Ning, Y. Sheng-Kang, Macromolecules 30, 4405 (1997)

    Article  CAS  Google Scholar 

  14. J.H. Stovbun, A.I. Kuzaev, S.M. Baturin, Polym. Sci. Ser A. 38, 691 (1996)

    Google Scholar 

  15. C.P.S. Sung, C.B. Hu, C.S. Wu, Macromolecules 13, 111 (1980)

    Article  CAS  Google Scholar 

  16. A. Takahara, R.W. Hergenrother, A.J. Coury, S.L. Cooper, J. Biomed. Mater. Res. 26, 801 (1992)

    Article  CAS  Google Scholar 

  17. B.D. Angeline, A. Hiltner, J.M. Anderson, in Degradable materials, perspectives, issues and opportunities, ed. by S.A. Barenberg, J.L. Brash, R. Narayan, A.R. Redpath (CRC Press, Boca Raton, FL, 1990), p. 295

  18. R. Manjari, V.C. Joseph, L.P. Pandureng, T. Sriram, J. Appl. Polym. Sci. 48, 271 (1993)

    Article  CAS  Google Scholar 

  19. A. Takahara, R.W. Hergenrother, A.J. Coury, S.L. Cooper, J. Biomed. Mater. Res. 25, 341 (1991)

    Article  CAS  Google Scholar 

  20. R.E. Marchant, Q. Zhao, J.M. Anderson, A. Hiltner, R.S. Ward, in Surface characterisation of biomaterials, ed. by B.D. Ratner (Elsevier, Amsterdam, 1988), p. 297

  21. R.E. Marchant, Q. Zhao, J.M. Anderson, A. Hiltner, Polymer 28, 2032 (1987)

    Article  CAS  Google Scholar 

  22. R.E. Marchant, Q. Zhao, J.M. Anderson, A. Hiltner, J. Biomed. Mater. Res. 20, 153 (1986)

    Article  CAS  Google Scholar 

  23. Q. Zhao, M.P. Agger, M. Fitzpatrick, J.M. Anderson, A. Hiltner, K. Stokes, P. Urbanski, J. Biomed. Mater. Res. 24, 621 (1990)

    Article  CAS  Google Scholar 

  24. V. Sa Da Costa, D. Brier-Russel, E.W. Salzman, E.W. Merrill, J. Colloid Interface Sci. 40, 445 (1981)

    Article  Google Scholar 

  25. A. Takahara, J. Tashita, T. Kajiyama, M. Takayanagi, J. Biomed. Mater. Res. 19, 13 (1985)

    Article  CAS  Google Scholar 

  26. S. Fare, P. Peterini, A. Motta, A. Cigada, M.C. Tanzi, J. Biomed. Mater. Res. 45, 62 (1999)

    Article  CAS  Google Scholar 

  27. J.P. Santerre, R.S. Labow, G.A. Adams, J. Biomed. Mater. Res. 27, 97 (1993)

    Article  CAS  Google Scholar 

  28. E.A. Ismail, H.A. Aziz, J. Polym. Mater. 17, 439 (2000)

    CAS  Google Scholar 

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Acknowledgements

The authors thank Department of Biotechnology, New Delhi, Government of India for financial assistance. The authors thank Dr. K. Mohandas, Director SCTIMST and Dr. G. S. Bhuvaneshwar, Head, BMT Wing for their support. The authors also thank Dr. Roy Joseph and Dr. P. Ramesh for their assistance for mechanical tests.

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Affiliations

  1. Polymer Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, 695 012, India

    Vinoy Thomas & Jayabalan Muthu

  2. Department of Physics/Materials Science and Engineering, Centre for Nanoscale Biomaterials and Biosensors (CNBB), University of Alabama at Birmingham (UAB), Birmingham, AL, USA

    Vinoy Thomas

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  1. Vinoy Thomas
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  2. Jayabalan Muthu
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Correspondence to Jayabalan Muthu.

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Thomas, V., Muthu, J. Biomechanical studies on aliphatic physically crosslinked poly(urethane urea) for blood contact applications. J Mater Sci: Mater Med 19, 2721–2733 (2008). https://doi.org/10.1007/s10856-008-3367-8

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  • DOI: https://doi.org/10.1007/s10856-008-3367-8

Keywords

  • Crosslink Density
  • Papain
  • Hard Segment
  • Soft Segment
  • Hard Segment Content