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Bioactive microspheres produced from gelatin–siloxane hybrids for bone regeneration

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Abstract

In this study, we produced a novel microsphere with a hybridized composition of gelatin and siloxane which is bioactive and degradable for the applications in bone regeneration fields. A solution of gelatin organic and siloxane inorganic containing calcium chloride was formulated into microspheres in an oil bath mediated by a surfactant. Following the processes of hydration, gelation and solidification, well-shaped spherical particles were produced with sizes of a few to hundreds of micrometers (68 μm on average). The obtained microspheres were highly stable in an aqueous solution due to the in situ cross-linking of the siloxane with gelatin chains, which eliminated the additional cross-linking step generally used in pure gelatin. The hybridized microspheres exhibited rapid induction of apatite-like crystals on their surface with incubation in a simulated body fluid, suggesting an excellent bone bioactivity in vitro. It is considered that the newly developed organic–inorganic microspheres may be useful for the regeneration of skeletal defects.

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Authors and Affiliations

  1. School of Materials Science and Engineering, Seoul National University, Seoul, 151-742, Korea

    Byung-Ho Yoon & Hyoun-Ee Kim

  2. Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan, 330-714, Korea

    Hae-Won Kim

  3. Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, 330-714, Korea

    Hae-Won Kim

Authors
  1. Byung-Ho Yoon
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  2. Hyoun-Ee Kim
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  3. Hae-Won Kim
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Correspondence to Hae-Won Kim.

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Yoon, BH., Kim, HE. & Kim, HW. Bioactive microspheres produced from gelatin–siloxane hybrids for bone regeneration. J Mater Sci: Mater Med 19, 2287–2292 (2008). https://doi.org/10.1007/s10856-007-3332-y

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  • DOI: https://doi.org/10.1007/s10856-007-3332-y

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