Skip to main content
SpringerLink
Log in

In vitro heat generation by ferrimagnetic maghemite microspheres for hyperthermic treatment of cancer under an alternating magnetic field

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

Ferrimagnetic materials can be expected to be useful as thermo seeds for hyperthermic treatment of cancer, especially where the cancer is located in deep parts of body, as they can generate heat by magnetic hysteretic loss when they are placed in an alternating magnetic field. Recently, it was reported that ferrimagnetic maghemite (γ-Fe2O3) microspheres 20–30 μm in diameter prepared in aqueous solution can show excellent heat generating ability. However, these microspheres have many cracks on their surfaces. In this study, the preparation conditions for the microspheres was further optimized in order to obtain crack-free ferrimagnetic microspheres, and the in vitro heat generation of the obtained microspheres was measured in an agar phantom under an alternating magnetic field. Crack-free γ-Fe2O3 microspheres 20–30 μm in diameter were obtained successfully. Their saturation magnetization and coercive force were 68 emu g−1 and 198 Oe, respectively. Their heat generation under an alternating magnetic field of 300 Oe at 100 kHz was estimated to be 42 W g−1. The microspheres showed in vitro heat generation when they were dispersed in an agar phantom and placed under an alternating magnetic field. It is believed that these microspheres may be useful for the in situ hyperthermic treatment of cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. J. CONWAY and A. P. ANDERSON, Clin. Phys. Physiol. Meas. 7 (1986) 287

    Article  CAS  Google Scholar 

  2. T. SUGIHARA, “Gan-to-Tatakau-Hyperthermia (Japanese)”, (Kyoto, Kinpoudou, 1986) p. 37–48

  3. R. CAVALIERE, E. C. CIOCATTO, B. C. GIOVANELLA, C. HEIDELBERGER, R. O. JOHNSON, M. MARGOTTINI, B. MONDOVI, G. MORICCA and A. ROSSI-FANELLI, Cancer 20 (1967) 1351

    Article  CAS  Google Scholar 

  4. K. OVERGAARD and J. OVERGAARD, Eur. J. Cancer 8 (1972) 65

    CAS  Google Scholar 

  5. K. OVERGAARD and J. OVERGAARD, Eur. J. Cancer 8 (1972) 573

    CAS  Google Scholar 

  6. J. OVERGAARD, Cancer 39 (1977) 2637

    Article  CAS  Google Scholar 

  7. N. F. BORRELLI, A. A. LUDERER, J. N. PANZARINO and H. L. RITTLER, Am. Ceram. Soc. Bull. 61 (1982) 819

    Google Scholar 

  8. A. A. LUDERER, N. F. BORRELLI, J. N. PANZARINO, G. R. MANSFIELD, D. M. HESS, J. L. BROWN, E. H. BARNETT and E. W. HAHN, Radiat. Res. 94 (1983) 190

    Article  CAS  Google Scholar 

  9. N. F. BORRELLI, A. A. LUDERER and J. N. PANZARINO, Phys. Med. Biol. 29 (1984) 487

    Article  CAS  Google Scholar 

  10. T. KOKUBO, Y. EBISAWA, Y. SUGIMOTO, M. KIYAMA, K. OHURA, T. YAMAMURO, M. HIRAOKA, M. ABE, In “Bioceramics Vol. 3”, edited by J. E. HULBERT and S. F. HULBERT (Rose-Hulman Institute of Technology, Indiana, 1992) p. 213

  11. Y. EBISAWA, Y. SUGIMOTO, T. HAYASHI, T. KOKUBO, K. OHURA and T. YAMAMURO, J. Ceram. Soc. Japan. 99 (1991) 7

    CAS  Google Scholar 

  12. Y. EBISAWA, T. KOKUBO, K. OHURA and T. YAMAMURO, J. Mater. Sci. Mater. Med. 1 (1990) 239

    Article  CAS  Google Scholar 

  13. Y. EBISAWA, T. KOKUBO, K. OHURA and T. YAMAMURO, J. Mater. Sci. Mater. Med. 4 (1993) 225

    Article  CAS  Google Scholar 

  14. K. OHURA, M. IKENAGA, T. NAKAMURA, T. YAMAMURO, Y. EBISAWA, T. KOKUBO, Y. KOTOURA and M. OKA, J. Appl. Biomater. 2 (1991) 153

    Article  CAS  Google Scholar 

  15. M. IKENAGA, K. OHURA, T. NAKAMURA, Y. KOTOURA, T. YAMAMURO, M. OKA, Y. EBISAWA, T. KOKUBO, in “Bioceramics Vol. 4”, edited by W. BONFIELD, G. W. HASTINGS and K. E. TANNER (Butterworth–Heinemann Ltd, Oxford, 1991) p. 255

  16. M. IKENAGA, K. OHURA, T. YAMAMURO, Y. KOTOURA, M. OKA and T. KOKUBO, J. Orthop. Res. 11 (1993) 849

    Article  CAS  Google Scholar 

  17. Y. EBISAWA, F. MIYAJI, T. KOKUBO, K. OHURA and T. NAKAMURA, J. Ceram. Soc. Japan 105 (1997) 947

    CAS  Google Scholar 

  18. Y. EBISAWA, F. MIYAJI, T. KOKUBO, K. OHURA and T. NAKAMURA, Biomaterials 18 (1977) 1277

    Article  Google Scholar 

  19. H. KONAKA, F. MIYAJI and T. KOKUBO, J. Ceram. Soc. Japan 105 (1997) 833

    CAS  Google Scholar 

  20. M. KAWASHITA, H. TAKAOKA, T. KOKUBO, T. YAO, S. HAMADA and T. SHINJO, J. Ceram. Soc. Japan 109 (2001) 39

    CAS  Google Scholar 

  21. S. H. OH, S. Y. CHOI, Y. K. LEE and K. N. KIM, J. Biomed. Mater. Res. 54 (2001) 360

    Article  CAS  Google Scholar 

  22. Y. K. LEE, S. B. LEE, Y. U. KIM, K. N. KIM, S. Y. CHOI, K. H. LEE, I. B. SHIM and C. S. KIM, J. Mater. Sci. 38 (2003) 4221

    Article  CAS  Google Scholar 

  23. M. KAWASHITA, Y. IWAHASHI, T. KOKUBO, T. YAO, S. HAMADA and T. SHINJO, J. Ceram. Soc. Japan 112 (2004) 373

    Article  CAS  Google Scholar 

  24. O. BRETCANU, S. SPRIANO, E. VERNE, M. COISSON, P. TIBERTO and P. ALLIA, Acta. Biomater. 1 (2005) 421

    Article  CAS  Google Scholar 

  25. T. LEVENTOURI, A. C. KIS, J. R. THOMPSON and I. M. ANDERSON, Biomaterials 26 (2005) 4924

    Article  CAS  Google Scholar 

  26. O. BRETCANU, S. SPRIANO, C. B. VITALE and E. VERNE, J. Mater. Sci. 41 (2006) 1029

    Article  CAS  Google Scholar 

  27. O. BRETCANU, E. VERNE, M. COISSON, P. TIBERTO and P. ALLIA, J. Magn. Magn. Mater. 300 (2006) 412

    Article  CAS  Google Scholar 

  28. O. BRETCANU, E. VERNE, M. COISSON, P. TIBERTO and P. ALLIA, J. Magn. Magn. Mater. 305 (2006) 529

    Article  CAS  Google Scholar 

  29. P. MOROZ, S. K. JONES, J. WINTER and B. N. GRAY, J. Surg. Oncol. 78 (2001) 22

    Article  CAS  Google Scholar 

  30. P. MOROZ, S. K. JONES and B. N. GRAY, J. Surg. Oncol. 80 (2002) 149

    Article  Google Scholar 

  31. P. MOROZ, S. K. JONES, C. METCALF and B. N. GRAY, Int. J. Hypertherm. 19 (2003) 23

    Article  CAS  Google Scholar 

  32. N. TSAFNAT, G. TSAFNAT, T. D. LAMBERT and S. K. JONES, Phys. Med. Biol. 50 (2005) 2937

    Article  CAS  Google Scholar 

  33. M. KAWASHITA, M. TANAKA, T. KOKUBO, T. YAO, S. HAMADA and T. SHINJO, Biomaterials 26 (2005) 2231

    Article  CAS  Google Scholar 

  34. A. Y. MATLOUBIEH, R. B. ROEMER and T. C CEATS, IEEE Trans. Biomed. Eng. 32 (1984) 227

    Article  Google Scholar 

  35. J. E. KNOWLES, J. Magn. Magn. Mater. 25 (1981) 105

    Article  CAS  Google Scholar 

  36. A. AHARONI, IEEE Trans. Magn. 22 (1986) 478

    Article  Google Scholar 

  37. Y. D. YAN and E. DELLA TORRE, IEEE Trans. Magn. 25 (1989) 2919

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported in part by a Grant-in-Aid for Scientific Research, the Ministry of Education, Culture, Sports, Science and Technology, Japan and Nanotechnology Support Project of the Ministry of Education, Culture, Sports, Science and Technology, Japan.

Author information

Authors and Affiliations

  1. Photonics and Electronics Science and Engineering Center, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510, Japan

    Masakazu Kawashita

  2. Technical Research Laboratory, Nippon Sheet Glass Co., Ltd, Itami-shi, Hyogo, 664-8520, Japan

    Shinjiro Domi & Yasuhiro Saito

  3. NEOMAX Co., Ltd, Kishima-gun, Saga, 849-2102, Japan

    Masaaki Aoki

  4. Sumikin Molycorp, Co., Ltd, Minato, Wakayama, 640-8404, Japan

    Yukihiro Ebisawa

  5. Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai-shi, Aichi, 487-8501, Japan

    Tadashi Kokubo

  6. Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan

    Takashi Saito & Mikio Takano

  7. Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, 606-8507, Japan

    Norio Araki & Masahiro Hiraoka

Authors
  1. Masakazu Kawashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Shinjiro Domi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yasuhiro Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masaaki Aoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yukihiro Ebisawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Tadashi Kokubo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takashi Saito
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mikio Takano
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Norio Araki
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Masahiro Hiraoka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masakazu Kawashita.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kawashita, M., Domi, S., Saito, Y. et al. In vitro heat generation by ferrimagnetic maghemite microspheres for hyperthermic treatment of cancer under an alternating magnetic field. J Mater Sci: Mater Med 19, 1897–1903 (2008). https://doi.org/10.1007/s10856-007-3262-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-007-3262-8

Keywords

Search

Navigation