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Poly(2-hydroxyethyl methacrylate) emboli with increased haemostatic effect for correction of haemorrhage of complex origin in endovascular surgery of children

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Abstract

Poly(2-hydroxyethyl methacrylate) (PHEMA) embolization particles with enhanced haemostatic properties were prepared by bulk or suspension polymerisation of 2-hydroxyethyl methacrylate (HEMA) followed by particle soaking in ethamsylate solution. The particles accelerated thrombus formation as evidenced by blood analysis of rabbits with implanted emboli. Usefulness of both spherical and cylindrical PHEMA particles with enhanced haemostatic effect was demonstrated on the embolization of arterial anastomosis, fistulas of the lower extremity and abdominal cavity, haemangioma and arteriovenous malformation of the head of several children.

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Acknowledgement

Financial support of the Center for Cell Therapy and Tissue Repair No. 1M0021620803 and Grant Agency of AS CR (grant KAN201110651) is gratefully acknowledged.

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Authors and Affiliations

  1. Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovsky Sq. 2, Prague 6, 162 06, Czech Republic

    Daniel Horák

  2. Filatov Children City Hospital No. 13, Sadovaya Kudrinskaya 15, Moscow, 123 001, Russia

    Ilya E. Galibin, Vladimir V. Shafranov & Yurii F. Isakov

  3. Vishnevskii Institute of Surgery, Russian Academy of Medical Sciences, Bolshaya Serpukhovskaya 27, Moscow, 115 093, Russia

    Arnold A. Adamyan, Alexander V. Sitnikov, Vasilii N. Dan, Mariya I. Titova & Tatyana I. Vinokurova

  4. Institute of Chemical Physics, Russian Academy of Sciences, Kosygina 4, Moscow, 119 991, Russia

    Klara Z. Gumargalieva

Authors
  1. Daniel Horák
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  2. Ilya E. Galibin
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  3. Arnold A. Adamyan
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  10. Tatyana I. Vinokurova
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Correspondence to Daniel Horák.

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Horák, D., Galibin, I.E., Adamyan, A.A. et al. Poly(2-hydroxyethyl methacrylate) emboli with increased haemostatic effect for correction of haemorrhage of complex origin in endovascular surgery of children. J Mater Sci: Mater Med 19, 1265–1274 (2008). https://doi.org/10.1007/s10856-007-3236-x

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  • DOI: https://doi.org/10.1007/s10856-007-3236-x

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