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In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process

Journal of Materials Science: Materials in Medicine volume 19, Article number: 553 (2008) Cite this article

Abstract

The in vitro response of the mouse fibroblast cell line 3T3 on the surface of ultrafine grained titanium [produced by a severe plastic deformation (SPD) process] has been studied in this work. SPD Ti showed much higher strength than the coarse grained Ti and equivalent to that of Ti–6Al–4V alloy. Better cell proliferation was observed on SPD Ti compared to conventional Ti and Ti–6Al–4V alloy. This could be attributed to the increased surface free energy by reduction in the grain size and possibly the presence of a large number of nano size grooves at the triple point junctions in SPD Ti sample. There was no significant difference in the results of cytotoxicity tests of fine and coarse grained materials.

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Acknowledgements

Authors wish to thank Paichai Bio-Medicinal Resources Research Center (RRC), Daejeon (Korea) and the Ministry of Education, Youth and Sport of the Czech Republic (project No. MSM 0021620806 and No. 1M0021620803) for their supports. Stay of Taik Nam Kim in Charles University, Prague, was covered by Rotary Club. Authors are grateful to Eva Vancova for the excellent technical assistance.

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Affiliations

  1. Department of Information and Electronic Materials Engineering, Paichai University, Daejeon, 302-735, Korea

    Taik Nam Kim, A. Balakrishnan & B. C. Lee

  2. Department of Dental Lab Technology, Daejeon Health Science College, Daejeon, 300-711, Korea

    W. S. Kim

  3. Charles University, 1st and 2nd Faculty of Medicine, Institute of Anatomy and Center of Cell Therapy and Tissue Repair, Prague, Czech Republic

    B. Dvorankova & K. Smetana

  4. Department of Materials Science and Engineering, KAIST, Daejeon, 305-701, Korea

    J. K. Park

  5. Division of Advanced Technology, Korea Research Institute of Standards & Science, Daejeon, 305-340, Korea

    B. B. Panigrahi

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  1. Taik Nam Kim
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  2. A. Balakrishnan
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  3. B. C. Lee
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  4. W. S. Kim
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  5. B. Dvorankova
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  8. B. B. Panigrahi
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Correspondence to Taik Nam Kim.

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Kim, T.N., Balakrishnan, A., Lee, B.C. et al. In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process. J Mater Sci: Mater Med 19, 553 (2008). https://doi.org/10.1007/s10856-007-3204-5

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  • DOI: https://doi.org/10.1007/s10856-007-3204-5

Keywords

  • Contact Angle
  • Severe Plastic Deformation
  • Severe Plastic Deformation Process
  • Conventional Titanium
  • Triple Point Junction