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Effects of calcination temperature on the drug delivery behaviour of Ibuprofen from hydroxyapatite powders

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Abstract

The effects of heat treatment time and temperature on the delivery behaviour of Ibuprofen from hydroxyapatite particles were investigated in this study. The drug release was seen to follow Fickian diffusion for the initial period of release for all heat treatment conditions. The gradient of Fickian release increased with (1) increasing crystallite size, attributed to the decreasing amount of boundary area, and (2) with decreasing surface area, due to the reduction in porosity and hence tortuosity within the apatite particles. This study has shown that altering the heat treatment conditions used to calcine hydroxyapatite may alter its drug delivery abilities, whereby calcination temperature was noted to influence the drug release behaviour to a greater extent than calcination time.

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References

  1. S. LADRÓN DE GUEVARA-FERNÁNDEZ, C. V. RAGEL, and M. VALLET-REGÍ, Biomaterials 24 (2003) 4037

    Article  CAS  Google Scholar 

  2. A. KRAJEWSKI, A. RAVAGLIOLI, E. RONCARI, P. PINASCO and L. MONTANARI, J. Mater. Sci.: Mater. Med. 12 (2000) 763

    Article  Google Scholar 

  3. L. DI SILVIO, and W. BONFIELD, J. Mater. Sci.: Mater. Med. 10 (1999) 653

    Article  Google Scholar 

  4. N. AHOLA, J. RICH, T. KARJALAINEN and J. SEPPALA, J. Appl. Polym. Sci. 88 (2003) 1279

    Article  CAS  Google Scholar 

  5. A. FERNANDEZ-CARBALLIDO, R. HERRERO-VANRELL, I. T. MOLINA-MARTINEZ and P. PASTORIZA, Int. J. Pharm. 279 (2004) 33

    Article  CAS  Google Scholar 

  6. F. DABBARH, A. RODRIGUES EL ZEIN and C. CHAPUT, Key Eng. Mater. 218–220 (2002) 17

    Article  Google Scholar 

  7. M. OTSUKA, Y. MATSUDA, D. YU, J. WONG, J. L. FOX and W. I. HIGUCHI, Chem. Pharm. Bull. 38 (1990) 3500

    CAS  Google Scholar 

  8. M. OTSUKA, Y. MATSUDA, Y. SUWA, J. L. FOX and W. I. HIGUCHI, J. Pharm. Sci. 83 (1994) 259

    Article  CAS  Google Scholar 

  9. J. GUICHEUX, G. GRIMANDI, M. TRECANT, A. FAIVRE, S. TAKAHASHI and G. DACULSI, J. Biomed. Mater. Res. 34 (1997) 165

    Article  CAS  Google Scholar 

  10. A. UCHIDA, Y. SHINTO, N. ARAKI and K. ONO, J. Orthop. Res. 10 (1992) 440

    Article  CAS  Google Scholar 

  11. M. SHIRKHANZADEH, M. AZADEGAN and G. Q. LIU, Mater. Lett. 24 (1995) 7

    Article  CAS  Google Scholar 

  12. V. MIDY, C. REY, E. BRES and M. DARD, J. Biomed. Mater. Res. 41 (1998) 405

    Article  CAS  Google Scholar 

  13. M. OTSUKA, Y. NAKAHIGASHI, Y. MATSUDA, J. L. FOX, W. I. HIGUCHI and Y. Sugiyama, J. Controlled Rel. 43 (1997) 115

    Article  Google Scholar 

  14. M. OTSUKA, Y. NAKAHIGASHI, Y. MATSUDA, J. L. FOX, W. I. HIGUCHI and Y. Sugiyama, J. Controlled Rel. 52 (1998) 281

    Article  CAS  Google Scholar 

  15. M. OTSUKA, Y. MATSUDA, Y. SUWA, J. L. FOX and W. I. HIGUCHI, J. Pharm. Sci. 83 (1994) 611

    Article  CAS  Google Scholar 

  16. W. PAUL and C. P. SHARMA, J. Mater. Sci.: Mater. Med. 10 (1999) 383

    Article  CAS  Google Scholar 

  17. R. MURUGAN and S. RAMAKRISHNA, J. Mater. Sci. 41 (2006) 4343

    Article  CAS  Google Scholar 

  18. P. L. RITGER and N. A. PEPPAS, J. Controlled Rel. 5 (1987) 23

    Article  CAS  Google Scholar 

  19. F. BARRERE, C. A. VAN BLITTERSWIJK, K. DE GROOT and P. LAYROLLE, Biomaterials 23 (2002) 2211

    Article  CAS  Google Scholar 

  20. J. P. CASSELLA, P. J. BARRIE, N. GARRINGTON and S. YOUSUF ALI, J. Bone Miner. Metab. 18 (2000) 291

    Article  CAS  Google Scholar 

  21. D. YU, J. WONG, Y. MATSUDA, J. L. FOX, W. I. HIGUCHI and M. OTSUKA, J. Pharm. Sci. 81 (1992) 529

    Article  CAS  Google Scholar 

  22. T. HIGUCHI, J. Pharm. Sci. 52 (1963) 1145

    Article  CAS  Google Scholar 

  23. V. C. A. MARTINS, G. GOISSIS, A. C. RIBEIRO, E. MARCANTONIO JR, M. R. BET, Artif. Organs 22 (1998) 215

    Article  CAS  Google Scholar 

  24. H. SESHIMA, M. YOSHINARI, S. TAKEMOTO, M. HATTORI, E. KAWADA, T. INOUE and Y. ODA, J. Biomed. Mater. Res. 78B (2006) 215

    Article  CAS  Google Scholar 

  25. V. S. KOMLEV, S. M. BARINOV and E. V. KOPLIK, Biomaterials 23 (2002) 3449

    Article  CAS  Google Scholar 

  26. W. D. J. CALLISTER, in “Materials Science and Engineering. An Introduction” (John Wiley & Sons, Inc, New York, 1985) p. 81

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Acknowledgements

A. J. Melville would like to thank the Monash University Postgraduate Publication Award scheme for funding during the preparation of this manuscript. L. M. Rodríguez-Lorenzo is supported by the Ramon y Cajal program, Spain. This work was supported by a Monash Research Fund grant and Australian Research Council grant F10017027 and A10017174.

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Authors and Affiliations

  1. Department of Materials Engineering, Division of Biological Engineering, Monash University, Melbourne, Australia

    Amanda J. Melville & John S. Forsythe

  2. Department Biomateriales, Instituto de Ciencia y tecnología de polímeros-CSIC, Madrid, Spain

    Luis M. Rodríguez-Lorenzo

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  1. Amanda J. Melville
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  2. Luis M. Rodríguez-Lorenzo
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  3. John S. Forsythe
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Correspondence to John S. Forsythe.

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Melville, A.J., Rodríguez-Lorenzo, L.M. & Forsythe, J.S. Effects of calcination temperature on the drug delivery behaviour of Ibuprofen from hydroxyapatite powders. J Mater Sci: Mater Med 19, 1187–1195 (2008). https://doi.org/10.1007/s10856-007-3185-4

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