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Characterization and in vitro degradation of poly(octadecanoic anhydride)

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Abstract

Poly(octadecanoic anhydride) (POA) has been prepared by melt polycondensation of octadecanoic diacid. POA was characterized by Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXD). The results of in vitro degradation and SEM micrographs show that the erosion process of POA is neither bulk nor perfect surface erosion but rather has elements of both in phosphate buffer at 37 °C. The moving erosion front is characteristic of surface erosion whereas the remaining porous shell stems from bulk erosion. While a significant special degradation property of POA is that POA presents a very slow degradation rate in acidic condition (pH 5.98), only 1.64% weight loss for 20 days, and it completely degrades after 18 days in basic buffer (pH 7.4). Comparing with poly(sebacic anhydride) (PSA), POA has the higher crystallization degree, and the slower hydrolytic rate.

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Acknowledgements

This work had been supported by Program for New Century Excellent Talents in University of China, the National Natural Science foundation of China (project 30170227) and the open foundation of State Key Laboratory of Biomembrane and Membrane Biotechnology of China.

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Authors and Affiliations

  1. Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    An-Jie Dong, Jin-Wei Zhang, Kai Jiang & Lian-Dong Deng

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  1. An-Jie Dong
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  2. Jin-Wei Zhang
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  3. Kai Jiang
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Correspondence to Lian-Dong Deng.

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Dong, AJ., Zhang, JW., Jiang, K. et al. Characterization and in vitro degradation of poly(octadecanoic anhydride). J Mater Sci: Mater Med 19, 39–46 (2008). https://doi.org/10.1007/s10856-007-3166-7

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  • DOI: https://doi.org/10.1007/s10856-007-3166-7

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